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Gene Review

TEN1  -  Ten1p

Saccharomyces cerevisiae S288c

Synonyms: Protein telomeric pathways with STN1, Telomere length regulation protein TEN1, YLR010C
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High impact information on TEN1

  • Here, we show that co-overexpressing TEN1 with a truncated form of STN1 efficiently bypasses the essential role of CDC13 [1].
  • Thus, Stn1p and Ten1p control a Cdc13p-independent telomere capping mechanism that is coupled to the conventional DNA replication machinery [1].
  • Other, temperature-sensitive, mutants of TEN1 arrested at G(2)/M via activation of the Rad9-dependent DNA damage checkpoint [2].
  • We propose that Ten1 is required to regulate telomere length, as well as to prevent lethal damage to telomeric DNA [2].
  • These ten1 mutant cells were found to accumulate single-stranded DNA in telomeric regions of the chromosomes [2].

Biological context of TEN1

  • Increased dosage of STN1, especially in combination with increased dosage of TEN1, resulted in reduced telomere length that was indistinguishable from that in upf mutants [3].
  • Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p [1].
  • A binding defect between Stn1-13 and Ten1 was responsible for the long telomere phenotype of stn1-13 mutant cells [2].
  • Increasing the levels of Stn1p and Ten1p in Upf+ cells is sufficient to delay senescence [4].

Other interactions of TEN1

  • Moreover, rescue of the cdc13-1 mutation by STN1 was much improved when TEN1 was simultaneously overexpressed [2].


  1. Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p. Petreaca, R.C., Chiu, H.C., Eckelhoefer, H.A., Chuang, C., Xu, L., Nugent, C.I. Nat. Cell Biol. (2006) [Pubmed]
  2. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. Grandin, N., Damon, C., Charbonneau, M. EMBO J. (2001) [Pubmed]
  3. mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae. Dahlseid, J.N., Lew-Smith, J., Lelivelt, M.J., Enomoto, S., Ford, A., Desruisseaux, M., McClellan, M., Lue, N., Culbertson, M.R., Berman, J. Eukaryotic Cell (2003) [Pubmed]
  4. Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells. Enomoto, S., Glowczewski, L., Lew-Smith, J., Berman, J.G. Mol. Cell. Biol. (2004) [Pubmed]
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