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Gene Review

STN1  -  Stn1p

Saccharomyces cerevisiae S288c

Synonyms: D4456, Protein STN1, YD8554.15, YDR082W
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High impact information on STN1

  • These results establish Stn1 as the primary effector of chromosome end protection, whereas the principal function of Cdc13 is to provide a loading platform to recruit complexes that provide end protection and telomere replication [1].
  • We propose that Pol12, together with Stn1, plays a key role in linking telomerase action with the completion of lagging strand synthesis, and in a regulatory step required for telomere capping [2].
  • Instead, and again unlike mutations affecting POL1, pol12-216 is lethal in combination with a mutation in the telomere end-binding and capping protein Stn1 [2].
  • Significantly, Pol12 and Stn1 interact in both two-hybrid and biochemical assays, and their synthetic-lethal interaction appears to be caused, at least in part, by a loss of telomere capping [2].
  • We propose that Stn1 functions in telomere metabolism during late S phase in cooperation with Cdc13 [3].

Associations of STN1 with chemical compounds

  • Genetic analysis suggests that the Tell kinase exerts an effect in parallel with the Stn1 C terminus to counteract its inhibition of telomerase [4].

Biological context of STN1

  • Increased dosage of STN1, especially in combination with increased dosage of TEN1, resulted in reduced telomere length that was indistinguishable from that in upf mutants [5].
  • Additional mutants for STN1, which show a tighter arrest phenotype than stn1-13, were generated in order to perform genetic screens aiming at uncovering new regulators of telomerase [6].
  • Temperature-sensitive mutations in CDC13 and STN1, which are both essential genes, activate a DNA damage-dependent checkpoint which is the cause of the arrest seen in the mutant strains [6].
  • Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p [7].
  • Increasing the levels of Stn1p and Ten1p in Upf+ cells is sufficient to delay senescence [8].

Physical interactions of STN1


Regulatory relationships of STN1

  • The half-life of STN1 mRNA was not altered in upf mutant strains, suggesting that an NMD-controlled transcription factor regulates the levels of STN1 mRNA [5].
  • We propose that accurate regulation of telomerase recruitment by Cdc13 results from a coordinated balance between positive control by yKu70 and negative control by Stn1 [9].

Other interactions of STN1

  • Here, we show that co-overexpressing TEN1 with a truncated form of STN1 efficiently bypasses the essential role of CDC13 [7].
  • Moreover, rescue of the cdc13-1 mutation by STN1 was much improved when TEN1 was simultaneously overexpressed [10].
  • Increased levels of STN1 together with EST2 resulted in reduced telomeric silencing like that of upf mutants [5].
  • HSC82, which encodes a conserved molecular chaperone of the Hsp90 family, was thus isolated as a high-dosage suppressor of a temperature-sensitive mutation in STN1 [6].
  • Overexpression of HSC82 was found to correct the telomeric defect associated with stn1 mutations [6].


  1. Cdc13 delivers separate complexes to the telomere for end protection and replication. Pennock, E., Buckley, K., Lundblad, V. Cell (2001) [Pubmed]
  2. Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Grossi, S., Puglisi, A., Dmitriev, P.V., Lopes, M., Shore, D. Genes Dev. (2004) [Pubmed]
  3. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Grandin, N., Reed, S.I., Charbonneau, M. Genes Dev. (1997) [Pubmed]
  4. Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition. Puglisi, A., Bianchi, A., Lemmens, L., Damay, P., Shore, D. EMBO J. (2008) [Pubmed]
  5. mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae. Dahlseid, J.N., Lew-Smith, J., Lelivelt, M.J., Enomoto, S., Ford, A., Desruisseaux, M., McClellan, M., Lue, N., Culbertson, M.R., Berman, J. Eukaryotic Cell (2003) [Pubmed]
  6. Hsp90 levels affect telomere length in yeast. Grandin, N., Charbonneau, M. Mol. Genet. Genomics (2001) [Pubmed]
  7. Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p. Petreaca, R.C., Chiu, H.C., Eckelhoefer, H.A., Chuang, C., Xu, L., Nugent, C.I. Nat. Cell Biol. (2006) [Pubmed]
  8. Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells. Enomoto, S., Glowczewski, L., Lew-Smith, J., Berman, J.G. Mol. Cell. Biol. (2004) [Pubmed]
  9. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment. Grandin, N., Damon, C., Charbonneau, M. Mol. Cell. Biol. (2000) [Pubmed]
  10. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. Grandin, N., Damon, C., Charbonneau, M. EMBO J. (2001) [Pubmed]
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