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Gene Review

SMF3  -  putative divalent metal ion transporter SMF3

Saccharomyces cerevisiae S288c

Synonyms: Iron transporter SMF3, YLR034C
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High impact information on SMF3

  • Smf3p is not regulated by Bsd2p or by manganese ions and is not degraded in the vacuole [1].
  • Western analysis with antibody against Smf3p indicated that this transporter does not reach the plasma membrane and may function at the Golgi or post-Golgi complexes [2].
  • Yeast membrane proteins SMF1, SMF2, and SMF3 are homologues of the DCT1 metal ion transporter family [3].
  • Fet4p is not the only metal transporter that is negatively regulated by oxygen; we find that Rox1p also represses S. cerevisiae SMF3, proposed to function in vacuolar iron transport [4].
  • Iron regulation of SMF3 was dramatically reduced, but not completely eliminated, in strains lacking both the AFT1 and AFT2 iron regulatory factors [5].

Biological context of SMF3

  • Using SMF3-lacZ reporter constructs, we identified two distinct regions of the SMF3 promoter that contribute to iron regulation: (1) approx. nt -435 to -350 that contain dual consensus recognition sites for the Aft1 iron transcription factor; and (2) nt -348 to -247 that do not contain obvious Aft1 binding sites [5].

Anatomical context of SMF3

  • SMF2 (but not SMF3) mediated significant increases in both Fe(2+) and Na(+) transport compared with control oocytes [3].

Other interactions of SMF3

  • Smf1p and Smf2p are regulated at the post-translational level by manganese, whereas Smf3p is regulated by iron through a mechanism that, up until now, was unknown [5].


  1. Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Portnoy, M.E., Liu, X.F., Culotta, V.C. Mol. Cell. Biol. (2000) [Pubmed]
  2. The family of SMF metal ion transporters in yeast cells. Cohen, A., Nelson, H., Nelson, N. J. Biol. Chem. (2000) [Pubmed]
  3. Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. Chen, X.Z., Peng, J.B., Cohen, A., Nelson, H., Nelson, N., Hediger, M.A. J. Biol. Chem. (1999) [Pubmed]
  4. Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron. Jensen, L.T., Culotta, V.C. J. Mol. Biol. (2002) [Pubmed]
  5. The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Portnoy, M.E., Jensen, L.T., Culotta, V.C. Biochem. J. (2002) [Pubmed]
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