Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ECM22 - Ecm22p

Saccharomyces cerevisiae S288c

Synonyms: Extracellular mutant protein 22, Sterol regulatory element-binding protein ECM22, YLR228C

Davies, B.S. et al., Valachovic, M. et al., MacPherson, S. et al., Vik A, n.u.l.l. et al., Valachovic, M. et al.

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High impact information on ECM22

The equivalent mutation in ECM22 also greatly enhanced transcriptional activation [1].
The C-terminal regions of Upc2p and Ecm22p, which contained activation domains, also conferred regulation in response to sterol levels [1].
Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae [2].
Upc2p and Ecm22p may thereby coordinately regulate genes involved in sterol homeostasis in yeast [2].
A mutation in an otherwise nonessential ERG2 gene is synthetically lethal when combined with mutations in two transcription factors encoded by the UPC2 and ECM22 genes [3].

Associations of ECM22 with chemical compounds

UPC2 and ECM22 belong to a Zn(2)-Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans [4].
In Saccharomyces cerevisiae, two highly related transcriptional activators, Upc2p and Ecm22p, positively regulate the expression of genes involved in ergosterol synthesis (ERG genes) [5].

References

Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Davies, B.S., Wang, H.S., Rine, J. Mol. Cell. Biol. (2005) [Pubmed]
Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Vik A, n.u.l.l., Rine, J. Mol. Cell. Biol. (2001) [Pubmed]
A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. Valachovic, M., Wilcox, L.I., Sturley, S.L., Bard, M. Lipids (2004) [Pubmed]
Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Valachovic, M., Bareither, B.M., Shah Alam Bhuiyan, M., Eckstein, J., Barbuch, R., Balderes, D., Wilcox, L., Sturley, S.L., Dickson, R.C., Bard, M. Genetics (2006) [Pubmed]
Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. MacPherson, S., Akache, B., Weber, S., De Deken, X., Raymond, M., Turcotte, B. Antimicrob. Agents Chemother. (2005) [Pubmed]

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