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Gene Review

CDC73  -  Cdc73p

Saccharomyces cerevisiae S288c

Synonyms: Cell division control protein 73, RNA polymerase-associated protein CDC73, YLR418C
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High impact information on CDC73

  • Deletions of three yeast genes, SET2, CDC73, and DST1, involved in transcriptional elongation and/or chromatin metabolism were used in conjunction with genetic array technology to screen approximately 4700 yeast deletions and identify double deletion mutants that produce synthetic growth defects [1].
  • The presence of the Paf1/Cdc73 complex on ORFs in vivo suggests a novel function for this complex in elongation [2].
  • In this work we demonstrate that Ccr4p and Hpr1p are components of the Paf1p-Cdc73p-Pol II complex [3].
  • Paf1p and Cdc73p were previously reported to be RNA poly-merase II-associated proteins, suggesting that the Ctr9p complex may interact with the general transcription apparatus [4].
  • Genome-wide expression analysis of a Saccharomyces cerevisiae strain deleted for the Tup1p-interacting protein Cdc73p [5].

Biological context of CDC73

  • Additionally, as previously observed for hpr1Delta, deleting PAF1 or CDC73 leads to elevated recombination between direct repeats [3].
  • Mutations in CDC73 and PAF1 affect cell growth and the abundance of transcripts from a subset of yeast genes (X. Shi et al., Mol. Cell. Biol., 1996 16, 669-676) [6].
  • Combination of the cdc73 mutation with the more severe paf1 mutation does not result in an enhanced phenotype, indicating that the two proteins may function in the same cellular processes [7].
  • Also isolated as RAPs are two proteins (Cdc73p and Paf1p) with interesting connections to gene expression [6].

Other interactions of CDC73

  • The Srbps and Cdc73p-Paf1p therefore appear to define two complexes with partially redundant, essential functions in the yeast cell [7].
  • Furthermore, our results indicate that Cdc73p plays a role in the repression of telomere-proximal genes, which are not repressed by Tup1p [5].
  • Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73 [8].


  1. A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Krogan, N.J., Keogh, M.C., Datta, N., Sawa, C., Ryan, O.W., Ding, H., Haw, R.A., Pootoolal, J., Tong, A., Canadien, V., Richards, D.P., Wu, X., Emili, A., Hughes, T.R., Buratowski, S., Greenblatt, J.F. Mol. Cell (2003) [Pubmed]
  2. Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Pokholok, D.K., Hannett, N.M., Young, R.A. Mol. Cell (2002) [Pubmed]
  3. A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Chang, M., French-Cornay, D., Fan, H.Y., Klein, H., Denis, C.L., Jaehning, J.A. Mol. Cell. Biol. (1999) [Pubmed]
  4. A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast. Koch, C., Wollmann, P., Dahl, M., Lottspeich, F. Nucleic Acids Res. (1999) [Pubmed]
  5. Genome-wide expression analysis of a Saccharomyces cerevisiae strain deleted for the Tup1p-interacting protein Cdc73p. Kerkmann, K., Lehming, N. Curr. Genet. (2001) [Pubmed]
  6. A novel collection of accessory factors associated with yeast RNA polymerase II. Wade, P.A., Werel, W., Fentzke, R.C., Thompson, N.E., Leykam, J.F., Burgess, R.R., Jaehning, J.A., Burton, Z.F. Protein Expr. Purif. (1996) [Pubmed]
  7. Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme. Shi, X., Chang, M., Wolf, A.J., Chang, C.H., Frazer-Abel, A.A., Wade, P.A., Burton, Z.F., Jaehning, J.A. Mol. Cell. Biol. (1997) [Pubmed]
  8. Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Reed, S.I., Ferguson, J., Jahng, K.Y. Cold Spring Harb. Symp. Quant. Biol. (1988) [Pubmed]
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