Gene Review:
HPR1 - Hpr1p
Saccharomyces cerevisiae S288c
Synonyms:
Hyperrecombination protein 1, THO complex subunit HPR1, YD9302.14, YDR138W
- The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Chávez, S., Aguilera, A. Genes Dev. (1997)
- A novel mechanism for telomere size control in Saccharomyces cerevisiae. Li, B., Lustig, A.J. Genes Dev. (1996)
- Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes. Abruzzi, K.C., Lacadie, S., Rosbash, M. EMBO J. (2004)
- HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Aguilera, A., Klein, H.L. Mol. Cell. Biol. (1990)
- High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability. Fan, H.Y., Merker, R.J., Klein, H.L. Mol. Cell. Biol. (2001)
- The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats. Santos-Rosa, H., Clever, B., Heyer, W.D., Aguilera, A. Genetics (1996)
- Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Libri, D., Dower, K., Boulay, J., Thomsen, R., Rosbash, M., Jensen, T.H. Mol. Cell. Biol. (2002)
- Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair. Piruat, J.I., Aguilera, A. Genetics (1996)
- Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants. Uemura, H., Pandit, S., Jigami, Y., Sternglanz, R. Genetics (1996)
- HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae. Zhu, Y., Peterson, C.L., Christman, M.F. Mol. Cell. Biol. (1995)
- The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation. Gwizdek, C., Hobeika, M., Kus, B., Ossareh-Nazari, B., Dargemont, C., Rodriguez, M.S. J. Biol. Chem. (2005)
- Genetic and molecular analysis of recombination events in Saccharomyces cerevisiae occurring in the presence of the hyper-recombination mutation hpr1. Aguilera, A., Klein, H.L. Genetics (1989)
- A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. Piruat, J.I., Aguilera, A. EMBO J. (1998)
- Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Zenklusen, D., Vinciguerra, P., Wyss, J.C., Stutz, F. Mol. Cell. Biol. (2002)