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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ATG17  -  Atg17p

Saccharomyces cerevisiae S288c

Synonyms: APG17, Autophagy-related protein 17, YLR423C
 
 
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High impact information on ATG17

  • In contrast, the ATG17 gene is required specifically in autophagy [1].
  • A point mutant of Atg17, Atg17(C24R), showed reduced affinity for Atg13, resulting in impaired Atg1 kinase activity and significant defects in autophagy [1].
  • Our mapping shows that the Atg11 coiled-coil domains are involved in self-assembly and the interaction with other proteins, including two previously unidentified partners, Atg17 and Atg20 [2].
  • Here, we identify Cis1/Atg31 as a protein that exhibits similar phenotypes to Atg17 [3].
  • Genome wide analyses have shown that Atg17 interacts with numerous proteins [3].

References

  1. Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., Ohsumi, Y. Mol. Biol. Cell (2005) [Pubmed]
  2. Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Yorimitsu, T., Klionsky, D.J. Mol. Biol. Cell (2005) [Pubmed]
  3. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Kabeya, Y., Kawamata, T., Suzuki, K., Ohsumi, Y. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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