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Gene Review

ATG11  -  Atg11p

Saccharomyces cerevisiae S288c

Synonyms: Autophagy-related protein 11, CVT3, CVT9, Cytoplasm to vacuole targeting protein 9, YP9499.07c, ...
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High impact information on ATG11

  • We propose that a pool of Atg11 mediates the anterograde transport of Atg9 to the PAS that is dependent on the actin cytoskeleton during yeast vegetative growth [1].
  • We also demonstrate that the integrity of the actin cytoskeleton is essential for correct targeting of Atg11 to the PAS [1].
  • We show that Atg11 governs Atg9 cycling through the PAS during specific autophagy [1].
  • Cvt9 oligomers peripherally associate with a novel, perivacuolar membrane compartment and interact with Apg1, a Ser/Thr kinase essential for both the Cvt pathway and autophagy [2].
  • Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole [2].

Anatomical context of ATG11

  • The deletion of CVT9 destabilizes the binding of prAPI to the membrane and analysis of a cvt9 temperature-sensitive mutant supports a direct role of Cvt9 in transport vesicle formation [2].
  • Nevertheless, Atg11, a protein that links receptor-bound cargo (peroxisomes, the Cvt complex) to the autophagic machinery was identified in all yeast species and filamentous fungi under study [3].

Associations of ATG11 with chemical compounds


Other interactions of ATG11

  • Accordingly, the deletion of APE1, ATG19, or ATG11 affected the formation of Cvt vesicles [5].
  • In particular, those factors are essential to correctly target the prApe1-Cvt19-Cvt9 complex to the preautophagosomal structure, the site of Cvt vesicle formation [6].


  1. Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast. He, C., Song, H., Yorimitsu, T., Monastyrska, I., Yen, W.L., Legakis, J.E., Klionsky, D.J. J. Cell Biol. (2006) [Pubmed]
  2. Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. Kim, J., Kamada, Y., Stromhaug, P.E., Guan, J., Hefner-Gravink, A., Baba, M., Scott, S.V., Ohsumi, Y., Dunn, W.A., Klionsky, D.J. J. Cell Biol. (2001) [Pubmed]
  3. ATG Genes Involved In Non-Selective Autophagy are Conserved from Yeast to Man, But the Selective Cvt and Pexophagy Pathways also Require Organism-Specific Genes. Meijer, W.H., van der Klei, I.J., Veenhuis, M., Kiel, J.A. Autophagy (2007) [Pubmed]
  4. Atg11 Directs Autophagosome Cargoes to the PAS Along Actin Cables. Monastyrska, I., Shintani, T., Klionsky, D.J., Reggiori, F. Autophagy. (2006) [Pubmed]
  5. Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. Shintani, T., Klionsky, D.J. J. Biol. Chem. (2004) [Pubmed]
  6. Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. Reggiori, F., Wang, C.W., Stromhaug, P.E., Shintani, T., Klionsky, D.J. J. Biol. Chem. (2003) [Pubmed]
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