The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ATG13  -  Atg13p

Saccharomyces cerevisiae S288c

Synonyms: APG13, Autophagy-related protein 13, YPR185W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ATG13

  • This Apg1-Apg13 association is required for autophagy, but not for the cytoplasm-to-vacuole targeting (Cvt) pathway, another vesicular transport mechanism in which factors essential for autophagy (Apg proteins) are also employed under vegetative growth conditions [1].
  • We also find that dephosphorylation of Apg13p, a signal transduction event that correlates with the onset of autophagy, is also independent of new protein synthesis [2].
  • Taken together, these results indicate that Atg17-Atg13 complex formation plays an important role in normal autophagosome formation via binding to and activating the Atg1 kinase [3].
  • Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting [4].
  • Subcellular fractionation of API indicates that Vac8p and Apg13p are involved in the vesicle formation step of the Cvt pathway [4].

Biological context of ATG13


Physical interactions of ATG13

  • Vac8p and Apg13p may be part of a larger protein complex that includes Apg1p and additional interacting proteins [4].

Other interactions of ATG13

  • Subcellular fractionation experiments indicate that Apg13p and a fraction of Apg1p are membrane-associated [4].

Analytical, diagnostic and therapeutic context of ATG13


  1. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., Ohsumi, Y. J. Cell Biol. (2000) [Pubmed]
  2. Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. Abeliovich, H., Dunn, W.A., Kim, J., Klionsky, D.J. J. Cell Biol. (2000) [Pubmed]
  3. Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., Ohsumi, Y. Mol. Biol. Cell (2005) [Pubmed]
  4. Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. Scott, S.V., Nice, D.C., Nau, J.J., Weisman, L.S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi, Y., Klionsky, D.J. J. Biol. Chem. (2000) [Pubmed]
WikiGenes - Universities