Disease relevance of UFD2

• The two human homologues of yeast UFD2 ubiquitination factor, UBE4A and UBE4B, are located in common neuroblastoma deletion regions and are subject to mutations in tumours [1].

High impact information on UFD2

• Cdc48-Ufd2-Rad23: the road less ubiquitinated [2]?
• Here, we demonstrate that the UBL motif of Rad23 also binds Ufd2, an E4 enzyme essential for ubiquitin chain assembly onto its substrates [3].
• Importantly, we also find that the ability of other UBL/UBA proteins to associate with Ufd2 correlates with their differential involvement in the UFD pathway, suggesting that UBL-mediated interactions may contribute to the substrate specificity of these adaptors [3].
• UFD1, UFD2, and UFD4 encode previously undescribed proteins of 40, 110, and 170 kDa, respectively [4].
• To determine the property of Ufd2, we reconstituted the UFD pathway using purified enzymes from yeast [5].

Biological context of UFD2

• Yeast Ufd2 is functionally implicated in cell survival under stressful conditions [6].

Other interactions of UFD2

• Mutations in the UBL of Rad23 alter its interactions with Ufd2 and the proteasome, and impair its function in the UFD proteolytic pathway [3].

References