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Gene Review

RPT2  -  proteasome regulatory particle base...

Saccharomyces cerevisiae S288c

Synonyms: 26S protease regulatory subunit 4 homolog, D2920, Tat-binding homolog 5, YDL007W, YHS4, ...
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High impact information on RPT2

  • Using a mutation in one of the ATPase subunits of the proteasome, RPT2, we demonstrate that Ime1, amino acids 270 to 360, is degraded by the 26S proteasome [1].
  • Expression of yeast RPT2 gene in T. brucei Rpt2-deficient cells could not rescue the lethal phenotype, thus confirming the incompatibility between the two Rpt2s [2].
  • In particular, mutations in one ATPase gene, RPT2, result in an unexpected defect in peptide hydrolysis by the core particle [3].


  1. Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Guttmann-Raviv, N., Martin, S., Kassir, Y. Mol. Cell. Biol. (2002) [Pubmed]
  2. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. Li, Z., Zou, C.B., Yao, Y., Hoyt, M.A., McDonough, S., Mackey, Z.B., Coffino, P., Wang, C.C. J. Biol. Chem. (2002) [Pubmed]
  3. Functional analysis of the proteasome regulatory particle. Glickman, M.H., Rubin, D.M., Fu, H., Larsen, C.N., Coux, O., Wefes, I., Pfeifer, G., Cjeka, Z., Vierstra, R., Baumeister, W., Fried, V., Finley, D. Mol. Biol. Rep. (1999) [Pubmed]
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