Gene Review:
rpt2 - 19S proteasome regulatory subunit Rpt2
Schizosaccharomyces pombe 972h-
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High impact information on mts2
- Finally, the phenotype for the mts2 mutant indicates that protein degradation by the 26S protease is essential not for entry into but for the completion of mitosis [1].
- The predicted amino-acid sequence of the cloned mts2+ gene product is 75% identical to the S4 subunit of the human 26S ATP/ubiquitin-dependent protease [1].
- The human S4 subunit complementary DNA expressed from an S. pombe expression plasmid can rescue an S. pombe mts2 gene disruption [1].
- We have isolated a mutant, mts2, in the fission yeast Schizosaccharomyces pombe which is defective in chromosome segregation [1].
References
- Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon, C., McGurk, G., Dillon, P., Rosen, C., Hastie, N.D. Nature (1993) [Pubmed]
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