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Gene Review

Psmc1  -  protease (prosome, macropain) 26S subunit,...

Mus musculus

Synonyms: 26S protease regulatory subunit 4, 26S proteasome AAA-ATPase subunit RPT2, AI325227, P26s4, Proteasome 26S subunit ATPase 1, ...
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Disease relevance of Psmc1

  • Genetic studies revealed that this difference is determined by S4, the viral gene segment that encodes sigma3. c43-derived subvirion particles that lack sigma3 replicated normally in P388D cells, suggesting that the difference in infectivity of Lang and c43 virions is at the level of sigma3 processing [1].

High impact information on Psmc1

  • Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site [2].


  1. Cathepsin S supports acid-independent infection by some reoviruses. Golden, J.W., Bahe, J.A., Lucas, W.T., Nibert, M.L., Schiff, L.A. J. Biol. Chem. (2004) [Pubmed]
  2. Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Koshio, H., Hirayama, F., Ishihara, T., Taniuchi, Y., Sato, K., Sakai-Moritani, Y., Kaku, S., Kawasaki, T., Matsumoto, Y., Sakamoto, S., Tsukamoto, S. Bioorg. Med. Chem. (2004) [Pubmed]
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