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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAD28  -  Rad28p

Saccharomyces cerevisiae S288c

Synonyms: Radiation-sensitive protein 28, YD9813.08c, YDR030C
 
 
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High impact information on RAD28

  • A strain deleted of the RAD26 gene, which is known to be required for strand-specific NER in yeast, manifested delayed recovery of mRNA synthesis, whereas a rad28 mutant, which does not show defective strand-specific repair, showed normal kinetics of recovery [1].
  • Additionally, the rate of repair of the transcribed and nontranscribed strands of the yeast RPB2 gene in the rad28 mutant is identical to that observed in wild-type cells following exposure to UV light [2].
  • A rad28 null mutant does not manifest increased sensitivity to killing by UV or gamma radiation or to methyl methanesulfonate [2].

References

  1. Recovery of RNA polymerase II synthesis following DNA damage in mutants of Saccharomyces cerevisiae defective in nucleotide excision repair. Reagan, M.S., Friedberg, E.C. Nucleic Acids Res. (1997) [Pubmed]
  2. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. Bhatia, P.K., Verhage, R.A., Brouwer, J., Friedberg, E.C. J. Bacteriol. (1996) [Pubmed]
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