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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ENA2  -  Na(+)-exporting P-type ATPase ENA2

Saccharomyces cerevisiae S288c

Synonyms: PMR2B, Sodium transport ATPase 2, YDR039C
 
 
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Disease relevance of ENA2

 

High impact information on ENA2

  • Two genes isolated from Schwanniomyces occidentalis, ENA1 and ENA2, encode P-type ATPases highly homologous to the Na-ATPases of Saccharomyces cerevisiae and complement the Na+ sensitivity of an S. cerevisiae mutant strain lacking its own Na-ATPases [2].
  • Here we identify two genes, PMR2B and LIC4 which, when overexpressed, suppress the cation-sensitive phenotype of yeast cells lacking calcineurin [3].
 

Anatomical context of ENA2

  • PMR2B encodes a Na+/Li+-specific plasma membrane pump and is similar to PMR2A, whose expression is known to be regulated by calcineurin [3].
 

Other interactions of ENA2

  • ENA1 and ENA2 are the first two units of a tandem array of four highly homologous genes with probably homologous functions [4].

References

  1. In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2. Leak, F.W., Tove, S., Parks, L.W. DNA Cell Biol. (1999) [Pubmed]
  2. P-type ATPases mediate sodium and potassium effluxes in Schwanniomyces occidentalis. Bañuelos, M.A., Rodríguez-Navarro, A. J. Biol. Chem. (1998) [Pubmed]
  3. Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Hemenway, C.S., Heitman, J. Mol. Gen. Genet. (1999) [Pubmed]
  4. Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Garciadeblas, B., Rubio, F., Quintero, F.J., Bañuelos, M.A., Haro, R., Rodríguez-Navarro, A. Mol. Gen. Genet. (1993) [Pubmed]
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