The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ATC1  -  Atc1p

Saccharomyces cerevisiae S288c

Synonyms: AIP3 complex protein 1, LIC4, Lithium comvertas protein 4, Protein ATC1/LIC4, YD9395.18c, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ATC1

  • These results strongly suggest that ATC1 is the structural gene encoding cell wall acid trehalase in C. albicans [1].
  • The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans [1].
  • Determinations of ATC1 mRNA expression as well as acid trehalase activity in the presence and absence of glucose point out that ATC1 gene is regulated by glucose repression [1].
  • After screening a Candida albicans genome data base, the product of an open reading frame (IPF 19760/CA2574) with 41% identity to Saccharomyces cerevisiae vacuolar acid trehalase (Ath1p) was identified and named Atc1p [1].
  • The deduced amino acid sequence shows that Atc1p contains an N-terminal hydrophobic signal peptide and 20 potential sites for N-glycosylation [1].

Biological context of ATC1


Associations of ATC1 with chemical compounds

  • Although loss of ARL1 confers several phenotypes, including sensitivity to hygromycin B and Li(+), reduced influx of K(+), and increased secretion of carboxypeptidase Y (CPY), loss of ATC1 was without effect by these and other measures [2].
  • LIC4 (lithium comvertas) encodes a novel 33-kDa protein with no identity to known proteins [3].

Other interactions of ATC1

  • Taken together, these observations suggest that calcineurin, Hal3, and Lic4 cooperatively regulate the response of yeast cells to cation stress [3].
  • Here we identify two genes, PMR2B and LIC4 which, when overexpressed, suppress the cation-sensitive phenotype of yeast cells lacking calcineurin [3].

Analytical, diagnostic and therapeutic context of ATC1

  • By indirect and direct immunofluorescence detection of HA- and GFP-tagged proteins, Lic4 is localized in the nucleus in wild-type cells but predominantly cytoplasmic in cells lacking calcineurin [3].


  1. The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans. Pedreño, Y., Maicas, S., Argüelles, J.C., Sentandreu, R., Valentin, E. J. Biol. Chem. (2004) [Pubmed]
  2. ARL1 participates with ATC1/LIC4 to regulate responses of yeast cells to ions. Munson, A.M., Love, S.L., Shu, J., Palanivel, V.R., Rosenwald, A.G. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Hemenway, C.S., Heitman, J. Mol. Gen. Genet. (1999) [Pubmed]
WikiGenes - Universities