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Gene Review:

cta3 - P-type ATPase, calcium transporting Cta3

Schizosaccharomyces pombe 972h-

Ghislain, M. et al., Halachmi, D. et al.

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High impact information on cta3

A new P-type ATPase gene, cta3, has been identified in Schizosaccharomyces pombe [1].
Calcium homeostasis and transport are affected by disruption of cta3, a novel gene encoding Ca2(+)-ATPase in Schizosaccharomyces pombe [1].
The sequence analysis and the physiological results strongly support the conclusion that the cta3 gene encodes a Ca2(+)-ATPase, probably located in intracellular membranes [1].
The cta3 protein contains 7 out of the 8 amino acid residues involved in high affinity Ca2+ binding in the sarcoplasmic reticulum Ca2(+)-ATPase from muscles [1].
The null mutation of cta3, a putative Ca2+ gene, [Ghislain, M., Goffeau, A., Halachmi, D. and Eilam, Y. (1990) J. Biol. Chem. 265, 18400-18407] strongly reduced the level of ATP-dependent Ca2+ uptake into non-vacuolar intracellular storing organelles [2].

References

Calcium homeostasis and transport are affected by disruption of cta3, a novel gene encoding Ca2(+)-ATPase in Schizosaccharomyces pombe. Ghislain, M., Goffeau, A., Halachmi, D., Eilam, Y. J. Biol. Chem. (1990) [Pubmed]
An intracellular ATP-dependent calcium pump within the yeast Schizosaccharomyces pombe, encoded by the gene cta3. Halachmi, D., Ghislain, M., Eilam, Y. Eur. J. Biochem. (1992) [Pubmed]

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AGOS_AGL097C	Ashbya gossypii ATCC 10895
KLLA0F20658g	Kluyveromyces lactis NRRL Y-1140
KLLA0E14587g	Kluyveromyces lactis NRRL Y-1140
MGG_02074	Magnaporthe oryzae 70-15
MGG_10730	Magnaporthe oryzae 70-15
NCU05046	Neurospora crassa OR74A
ENA1	Saccharomyces cerevisiae S288c
ENA2	Saccharomyces cerevisiae S288c
ENA5	Saccharomyces cerevisiae S288c

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