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Gene Review:

RSC3 - Rsc3p

Saccharomyces cerevisiae S288c

Synonyms: Chromatin structure-remodeling complex protein RSC3, D9740.13, Remodel the structure of chromatin complex subunit 3, YDR303C

Angus-Hill, M.L. et al., Takeuchi, S. et al., Wilson, B. et al.

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High impact information on RSC3

A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control [1].
RSC3 is essential, and rsc3 Ts- mutants display a G2/M cell cycle arrest involving the spindle assembly checkpoint pathway, whereas rsc30Delta mutants are viable and osmosensitive [1].
Thus, Rsc7 and Rsc14 have different roles in the module as well as sharing physical and functional connections to Rsc3 [2].
Interestingly, certain rsc7delta and rsc14delta phenotypes are suppressed by an increased dosage of Rsc3, an essential RSC member with roles in cell wall integrity and spindle checkpoint pathways [2].
The RSC3-E2R cell line was isolated from a lung metastatic focus following s.c. injection of RSC3-E2 cells after X-irradiation in vitro [3].

Anatomical context of RSC3

However, DNA microarray analysis with rsc3 or rsc30 mutants reveals different effects on the expression levels of ribosomal protein genes and cell wall genes [1].
These results suggest that the two undifferentiated RSC3-LM and RSC3-E2R tumor cell lines with different metastatic potential were generated from differentiated SCC cells via different genetic pathways as a consequence of tumor progression in vivo and in vitro, respectively [3].

References

A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Angus-Hill, M.L., Schlichter, A., Roberts, D., Erdjument-Bromage, H., Tempst, P., Cairns, B.R. Mol. Cell (2001) [Pubmed]
The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Wilson, B., Erdjument-Bromage, H., Tempst, P., Cairns, B.R. Genetics (2006) [Pubmed]
Isolation of differentiated squamous and undifferentiated spindle carcinoma cell lines with differing metastatic potential from a 4-nitroquinoline N-Oxide-induced tongue carcinoma in a F344 rat. Takeuchi, S., Nakanishi, H., Yoshida, K., Yamamoto, S., Tonoki, H., Tsukamoto, T., Fukushima, S., Moriuchi, T., Kurita, K., Tatematsu, M. Jpn. J. Cancer Res. (2000) [Pubmed]

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