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Gene Review

TFB1  -  TFIIH/NER complex subunit TFB1

Saccharomyces cerevisiae S288c

Synonyms: D9740.3, General transcription and DNA repair factor IIH subunit TFB1, RNA polymerase II transcription factor B 73 kDa subunit, RNA polymerase II transcription factor B p73 subunit, RNA polymerase II transcription factor B subunit 1, ...
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High impact information on TFB1

  • The gene that encodes the 73-kilodalton polypeptide, designated TFB1, was cloned and found to be essential for cell growth [1].
  • SSL1 protein interacts with itself and with RAD3 and TFB1 proteins in living yeast cells [2].
  • To address this, transcription initiation complexes have been formed with Pyrococcus furiosus transcription factors (TBP and TFB1), RNA polymerase, and a linear DNA fragment containing a strong promoter [3].
  • We found that ssl1, rad3 and tfb1 mutants, like rad25(ssl2-xp) mutants, are deficient in both the global NER and TCR pathways [4].
  • We isolated mutations in TFB1 that lead to a temperature sensitive phenotype [5].

Biological context of TFB1


Other interactions of TFB1

  • The essential TFB1 and SSL1 genes of the yeast Saccharomyces cerevisiae encode two subunits of the RNA polymerase II transcription factor TFIIH (factor b) [6].

Analytical, diagnostic and therapeutic context of TFB1

  • Immunoprecipitation experiments using antibodies to the TFB1 gene product demonstrate that the transcriptional and CTD kinase activities of factor b are closely associated with an oligomer of the three polypeptides [1].


  1. Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase. Gileadi, O., Feaver, W.J., Kornberg, R.D. Science (1992) [Pubmed]
  2. Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b. Bardwell, L., Bardwell, A.J., Feaver, W.J., Svejstrup, J.Q., Kornberg, R.D., Friedberg, E.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Topography of the euryarchaeal transcription initiation complex. Bartlett, M.S., Thomm, M., Geiduschek, E.P. J. Biol. Chem. (2004) [Pubmed]
  4. DNA repair deficiencies associated with mutations in genes encoding subunits of transcription initiation factor TFIIH in yeast. Sweder, K.S., Chun, R., Mori, T., Hanawalt, P.C. Nucleic Acids Res. (1996) [Pubmed]
  5. An interaction between the Tfb1 and Ssl1 subunits of yeast TFIIH correlates with DNA repair activity. Matsui, P., DePaulo, J., Buratowski, S. Nucleic Acids Res. (1995) [Pubmed]
  6. The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription. Wang, Z., Buratowski, S., Svejstrup, J.Q., Feaver, W.J., Wu, X., Kornberg, R.D., Donahue, T.F., Friedberg, E.C. Mol. Cell. Biol. (1995) [Pubmed]
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