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Gene Review

FIT1  -  Fit1p

Saccharomyces cerevisiae S288c

Synonyms: D9719.37, Facilitator of iron transport 1, YDR534C
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High impact information on FIT1

  • Some yeast mitochondrial introns encode proteins that promote either splicing (maturases) or intron propagation via gene conversion (the fit1 endonuclease) [1].
  • Fit1p was localized exclusively to the cell wall by indirect immunofluorescence [2].
  • To examine the requirement of the GPI anchoring on the plasma membrane for the function, the omega-minus region of Ybr078w was replaced with those of Ydr534c/Fit1 and Ynl327w/Egt2, which are known as GPI-dependent cell wall proteins [3].
  • One family of genes, FIT1, FIT2 and FIT3, codes for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors [4].
  • One contains a deletion of the dodecamer at the end of the var1 gene, and the other contains two adjacent transversions in the dodecamer at the end of the reading frame of fit1, a gene within the omega+ allele of the 21S rRNA gene [5].


  1. A latent intron-encoded maturase is also an endonuclease needed for intron mobility. Wenzlau, J.M., Saldanha, R.J., Butow, R.A., Perlman, P.S. Cell (1989) [Pubmed]
  2. Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae. Protchenko, O., Ferea, T., Rashford, J., Tiedeman, J., Brown, P.O., Botstein, D., Philpott, C.C. J. Biol. Chem. (2001) [Pubmed]
  3. The localization change of Ybr078w/Ecm33, a yeast GPI-associated protein, from the plasma membrane to the cell wall, affecting the cellular function. Terashima, H., Hamada, K., Kitada, K. FEMS Microbiol. Lett. (2003) [Pubmed]
  4. The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake. Philpott, C.C., Protchenko, O., Kim, Y.W., Boretsky, Y., Shakoury-Elizeh, M. Biochem. Soc. Trans. (2002) [Pubmed]
  5. The role of a conserved dodecamer sequence in yeast mitochondrial gene expression. Butow, R.A., Zhu, H., Perlman, P., Conrad-Webb, H. Genome (1989) [Pubmed]
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