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Gene Review

ILS1  -  isoleucine--tRNA ligase ILS1

Saccharomyces cerevisiae S288c

Synonyms: IleRS, Isoleucine--tRNA ligase, cytoplasmic, Isoleucyl-tRNA synthetase, YBL0734, YBL076C
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High impact information on ILS1

  • Moreover, overexpression of the ILS1 gene from a high-copy plasmid conferred RM-A resistance [1].
  • The fragment maps to chromosome II on the left arm between the CDC27 and ILS1 loci [2].
  • By hybridization to defined genomic clones the gene was mapped to chromosome II between cdc25 and ils1 [3].


  1. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto, Y., Machida, K., Mizunuma, M., Emoto, Y., Sato, N., Miyahara, K., Hirata, D., Usui, T., Takahashi, H., Osada, H., Miyakawa, T. J. Biol. Chem. (2002) [Pubmed]
  2. Sequence of a segment of yeast chromosome II shows two novel genes, one almost entirely hydrophobic and the other extremely asparagine-serine rich. Cusick, M.E. Yeast (1994) [Pubmed]
  3. PET112, a Saccharomyces cerevisiae nuclear gene required to maintain rho+ mitochondrial DNA. Mulero, J.J., Rosenthal, J.K., Fox, T.D. Curr. Genet. (1994) [Pubmed]
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