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Gene Review

CDC27  -  anaphase promoting complex subunit CDC27

Saccharomyces cerevisiae S288c

Synonyms: APC3, Anaphase-promoting complex subunit 3, Anaphase-promoting complex subunit CDC27, Cell division control protein 27, SNB1, ...
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High impact information on CDC27


Biological context of CDC27

  • Most of these mutants lie in the CDC16, CDC23, and CDC27 genes, which have already been shown to play a role in cyclin proteolysis and encode components of a 20S complex (called the cyclosome or anaphase promoting complex) that ubiquitinates mitotic cyclins [5].
  • Furthermore, the APC activator Cdc20 is itself a substrate of the Cdc27 have a role in the degradation of Cdc20 during S Phase and early mitosis that is not mediated by its destruction box [6].
  • Depletion of anaphase-promoting complex or cyclosome (APC/C) subunit homolog APC1 or CDC27 of Trypanosoma brucei arrests the procyclic form in metaphase but the bloodstream form in anaphase [4].
  • These observations distinguish CDC16 and CDC27 from other mutants that accumulate extra DNA after completing an aberrent mitosis, or skipping mitosis altogether, and entering a second, inappropriate G1 and S phase [1].
  • The fragment maps to chromosome II on the left arm between the CDC27 and ILS1 loci [7].

Other interactions of CDC27


Analytical, diagnostic and therapeutic context of CDC27


  1. The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Heichman, K.A., Roberts, J.M. Cell (1996) [Pubmed]
  2. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Zachariae, W., Shin, T.H., Galova, M., Obermaier, B., Nasmyth, K. Science (1996) [Pubmed]
  3. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. Lamb, J.R., Michaud, W.A., Sikorski, R.S., Hieter, P.A. EMBO J. (1994) [Pubmed]
  4. Depletion of anaphase-promoting complex or cyclosome (APC/C) subunit homolog APC1 or CDC27 of Trypanosoma brucei arrests the procyclic form in metaphase but the bloodstream form in anaphase. Kumar, P., Wang, C.C. J. Biol. Chem. (2005) [Pubmed]
  5. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Hwang, L.H., Murray, A.W. Mol. Biol. Cell (1997) [Pubmed]
  6. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Prinz, S., Hwang, E.S., Visintin, R., Amon, A. Curr. Biol. (1998) [Pubmed]
  7. Sequence of a segment of yeast chromosome II shows two novel genes, one almost entirely hydrophobic and the other extremely asparagine-serine rich. Cusick, M.E. Yeast (1994) [Pubmed]
  8. Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. Mo, J., Liu, L., Leon, A., Mazloum, N., Lee, M.Y. Biochemistry (2000) [Pubmed]
  9. The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit. Sanchez Garcia, J., Ciufo, L.F., Yang, X., Kearsey, S.E., MacNeill, S.A. Nucleic Acids Res. (2004) [Pubmed]
  10. Molecular cloning and sequence analysis of cdc27+ required for the G2-M transition in the fission yeast Schizosaccharomyces pombe. Hughes, D.A., MacNeill, S.A., Fantes, P.A. Mol. Gen. Genet. (1992) [Pubmed]
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