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Gene Review

TIM12  -  Tim12p

Saccharomyces cerevisiae S288c

Synonyms: MRS5, Mitochondrial import inner membrane translocase subunit TIM12, Mitochondrial regulator of splicing 5, YBR0812, YBR091C
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High impact information on MRS5

  • This interaction of Tim10 and Tim12 with the precursors depends on the presence of divalent metal ions [1].
  • Tim10 and Tim12 are found in a complex with Tim22, which takes over the precursor and mediates its membrane-potential-dependent insertion into the inner membrane [1].
  • Tim9, an essential protein of Saccharomyces cerevisiae, shares sequence similarity with Tim10 and Tim12 [2].
  • Elevated gene dosage of this new gene, termed MRS5, suppresses also the pet phenotype of a mitochondrial splicing-deficient group II intron mutation M1301 [3].
  • The MRS5 gene product, a 13-kDa protein of low abundance, shows no similarity to other known proteins and is associated with the inner mitochondrial membrane, protruding into the intermembrane space [3].

Biological context of MRS5

  • Interestingly, this new gene shares many similarities with the previously characterized MRS5 gene: when expressed from a multicopy plasmid, MRS11 like MRS5 restores respiration competence to yeast strains defective in the splicing of mitochondrial group II introns [4].
  • These findings suggest an essential role of Mrs5p in mitochondrial biogenesis [3].

Anatomical context of MRS5

  • Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria [3].

Other interactions of MRS5

  • Depletion of Mrs5p in yeast cells causes accumulation of unprocessed precursors of the mitochondrial hsp60 protein and defects in all cytochrome complexes [3].


  1. Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Sirrenberg, C., Endres, M., Fölsch, H., Stuart, R.A., Neupert, W., Brunner, M. Nature (1998) [Pubmed]
  2. Tim9, a new component of the TIM22.54 translocase in mitochondria. Adam, A., Endres, M., Sirrenberg, C., Lottspeich, F., Neupert, W., Brunner, M. EMBO J. (1999) [Pubmed]
  3. Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria. Jarosch, E., Tuller, G., Daum, G., Waldherr, M., Voskova, A., Schweyen, R.J. J. Biol. Chem. (1996) [Pubmed]
  4. A soluble 12-kDa protein of the mitochondrial intermembrane space, Mrs11p, is essential for mitochondrial biogenesis and viability of yeast cells. Jarosch, E., Rödel, G., Schweyen, R.J. Mol. Gen. Genet. (1997) [Pubmed]
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