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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RIM2  -  Rim2p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial carrier protein RIM2, YBR1402, YBR192W
 
 
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High impact information on RIM2

  • Antibodies directed against the aminoterminus of RIM2/MRS12 detect this protein in mitochondria [1].
  • In particular, a typical triplicate structure, where each repeat consists of two putative transmembrane segments separated by a hydrophilic loop, can be deduced from amino acid sequence comparisons and the hydropathy profile of RIM2/MRS12 [1].
  • The RIM2/MRS12 gene encodes a predicted protein of 377 amino acids that is essential for mitochondrial DNA metabolism and proper cell growth [1].
  • Furthermore, the Rim2p-mediated heteroexchanges, TTP/TMP and TTP/TDP, are electroneutral and probably H+-compensated [2].
  • Rim2p was strongly inhibited by mercurials, bathophenanthroline, tannic acid and Bromocresol Purple, and partially inhibited by bongkrekic acid [2].
 

Associations of RIM2 with chemical compounds

  • In the present study, Rim2p has been identified as a yeast mitochondrial pyrimidine nucleotide transporter [2].

References

  1. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Van Dyck, E., Jank, B., Ragnini, A., Schweyen, R.J., Duyckaerts, C., Sluse, F., Foury, F. Mol. Gen. Genet. (1995) [Pubmed]
  2. Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization. Marobbio, C.M., Di Noia, M.A., Palmieri, F. Biochem. J. (2006) [Pubmed]
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