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Gene Review

HSM3  -  Hsm3p

Saccharomyces cerevisiae S288c

Synonyms: DNA mismatch repair protein HSM3, Enhanced spontaneous mutability protein 3, YBR1740, YBR272C
 
 
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Disease relevance of HSM3

 

High impact information on HSM3

 

Regulatory relationships of HSM3

  • The hsm3 mutation suppressed synthetic lethality in the hsm3 pol3-01 pms1 triple mutant and dramatically increased the spontaneous mutation rate in comparison with double mutant [2].

References

  1. The yeast HSM3 gene acts in one of the mismatch repair pathways. Fedorova, I.V., Gracheva, L.M., Kovaltzova, S.V., Evstuhina, T.A., Alekseev, S.Y., Korolev, V.G. Genetics (1998) [Pubmed]
  2. Requirement of HSM3 gene for spontaneous mutagenesis in Saccharomyces cerevisiae. Fedorova, I.V., Kovaltzova, S.V., Gracheva, L.M., Evstuhina, T.A., Korolev, V.G. Mutat. Res. (2004) [Pubmed]
  3. HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae. Alekseev, S.Y., Kovaltsova, S.V., Fedorova, I.V., Gracheva, L.M., Evstukhina, T.A., Peshekhonov, V.T., Korolev, V.G. DNA Repair (Amst.) (2002) [Pubmed]
 
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