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HIS7  -  imidazoleglycerol-phosphate synthase

Saccharomyces cerevisiae S288c

Synonyms: IGP synthase, IGPS, ImGP synthase, Imidazole glycerol phosphate synthase hisHF, YBR1640, ...
 
 
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Disease relevance of HIS7

 

High impact information on HIS7

  • Multiple factors prevent transcriptional interference at the yeast ARO4-HIS7 locus [3].
  • The abolishment of the Abf1p-binding site within the HIS7 promoter significantly enhances transcriptional interference, resulting in a histidine auxotrophic strain [3].
  • The open reading frames of ARO4 and HIS7 are tandemly transcribed and are separated by 416 bp [3].
  • Under conditions of simultaneous amino acid starvation and adenine limitation the effects of GCN4p and BAS1/2p are additive and both factors are necessary for maximal HIS7 transcription [4].
  • The HIS7 gene is activated by GCN4p under environmental conditions of amino acid starvation through two synergistic upstream sites GCRE1 and GCRE2 [4].
 

Biological context of HIS7

 

Associations of HIS7 with chemical compounds

 

Regulatory relationships of HIS7

 

Other interactions of HIS7

  • Tetrad analysis of crosses between rib5 and other markers on chromosome II shows that the RIB5 gene is located on the right arm of this chromosome, closely linked to HIS7 [12].
  • DPB3 was mapped to chromosome II, 30 cM distal to his7 [13].
  • Each of the his1-his7 mutant strains were unable to grow in the presence of elevated levels of Cu, Co, or Ni at nearly neutral pHs, in contrast to His(+) strains, which grew under these conditions [14].
  • Regulation of the yeast HIS7 gene by the global transcription factor Abf1p [15].
  • The locus of CAD2 was mapped by gene linkage to a site 15.5 centimorgans to the right of the his7 locus on the right arm of chromosome II [16].
 

Analytical, diagnostic and therapeutic context of HIS7

  • The fused structural feature of the HIS7 protein and the development of a high-level production system for the active enzyme elevate the potential for determination of its three-dimensional structure through X-ray crystallography [17].

References

  1. Nucleosome position-dependent and -independent activation of HIS7 epression in Saccharomyces cerevisiae by different transcriptional activators. Valerius, O., Brendel, C., Wagner, C., Krappmann, S., Thoma, F., Braus, G.H. Eukaryotic Cell (2003) [Pubmed]
  2. Mechanism for acivicin inactivation of triad glutamine amidotransferases. Chittur, S.V., Klem, T.J., Shafer, C.M., Davisson, V.J. Biochemistry (2001) [Pubmed]
  3. Multiple factors prevent transcriptional interference at the yeast ARO4-HIS7 locus. Valerius, O., Brendel, C., Düvel, K., Braus, G.H. J. Biol. Chem. (2002) [Pubmed]
  4. Amino acid and adenine cross-pathway regulation act through the same 5'-TGACTC-3' motif in the yeast HIS7 promoter. Springer, C., Künzler, M., Balmelli, T., Braus, G.H. J. Biol. Chem. (1996) [Pubmed]
  5. The yeast HSM3 gene acts in one of the mismatch repair pathways. Fedorova, I.V., Gracheva, L.M., Kovaltzova, S.V., Evstuhina, T.A., Alekseev, S.Y., Korolev, V.G. Genetics (1998) [Pubmed]
  6. Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae. Kuenzler, M., Balmelli, T., Egli, C.M., Paravicini, G., Braus, G.H. J. Bacteriol. (1993) [Pubmed]
  7. The origin and evolution of eucaryal HIS7 genes: from metabolon to bifunctional proteins? Brilli, M., Fani, R. Gene (2004) [Pubmed]
  8. Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Fani, R., Tamburini, E., Mori, E., Lazcano, A., Liò, P., Barberio, C., Casalone, E., Cavalieri, D., Perito, B., Polsinelli, M. Gene (1997) [Pubmed]
  9. Fluphenazine-resistant Saccharomyces cerevisiae mutants defective in the cell division cycle. Matsumoto, K., Uno, I., Ishikawa, T. J. Bacteriol. (1986) [Pubmed]
  10. Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases. Lee, Y.H., Ogata, C., Pflugrath, J.W., Levitt, D.G., Sarma, R., Banaszak, L.J., Pilkis, S.J. Biochemistry (1996) [Pubmed]
  11. An Arabidopsis cDNA encoding a bifunctional glutamine amidotransferase/cyclase suppresses the histidine auxotrophy of a Saccharomyces cerevisiae his7 mutant. Fujimori, K., Ohta, D. FEBS Lett. (1998) [Pubmed]
  12. Mapping of the rib5 gene in Saccharomyces cerevisiae using UV light as an enhancer of rad52-mediated chromosome loss. Santos, M.A., Iturriaga, E.A., Eslava, A.P. Curr. Genet. (1988) [Pubmed]
  13. Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Araki, H., Hamatake, R.K., Morrison, A., Johnson, A.L., Johnston, L.H., Sugino, A. Nucleic Acids Res. (1991) [Pubmed]
  14. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce, D.A., Sherman, F. J. Bacteriol. (1999) [Pubmed]
  15. Regulation of the yeast HIS7 gene by the global transcription factor Abf1p. Springer, C., Krappmann, S., Künzler, M., Zmasek, C., Braus, G.H. Mol. Gen. Genet. (1997) [Pubmed]
  16. Resistance to cadmium is under control of the CAD2 gene in the yeast Saccharomyces cerevisiae. Tohoyama, H., Inouhe, M., Joho, M., Murayama, T. Curr. Genet. (1990) [Pubmed]
  17. Expression and purification of imidazole glycerol phosphate synthase from Saccharomyces cerevisiae. Chittur, S.V., Chen, Y., Davisson, V.J. Protein Expr. Purif. (2000) [Pubmed]
 
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