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Gene Review:

SUA5 - Sua5p

Saccharomyces cerevisiae S288c

Synonyms: G1660, L-threonylcarbamoyladenylate synthase, Suppressor of upstream AUG protein 5, TC-AMP synthase, Threonylcarbamoyl-AMP synthase, ...

Na, J.G. et al., Hampsey, M. et al.

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High impact information on SUA5

SUA5 was mapped to chromosome VII, immediately adjacent to the PMR1 gene [1].
Disruption of SUA5 conferred the same Cyc+ and Slg- phenotypes as the sua5-1 suppressor, which is the result of a missense mutation, encoding a Ser107----Phe replacement [1].
Neither the SUA5 DNA sequence nor deduced amino acid sequence showed homology to any sequences in the data banks [1].
The SUA5 wild-type gene was isolated and sequenced, revealing an open reading frame (ORF) encoding a potential protein of 46,537 Da [1].
These results define SUA5 as a new gene encoding a novel protein that is necessary for normal cell growth [1].

Biological context of SUA5

These phenotypes have been exploited to clone the SUA5, SUA7 and SUA8 genes, which are presently being characterized [2].

Associations of SUA5 with chemical compounds

In addition, sua5 null mutants lack cytochrome a.a3 and fail to grow on lactate or glycerol medium [1].

Other interactions of SUA5

We have identified the sua5 locus as a suppressor of an aberrant ATG codon located in the leader region of the cyc1 gene [1].

References

Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae. Na, J.G., Pinto, I., Hampsey, M. Genetics (1992) [Pubmed]
Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Hampsey, M., Na, J.G., Pinto, I., Ware, D.E., Berroteran, R.W. Biochimie (1991) [Pubmed]

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AGOS_AEL300C	Ashbya gossypii ATCC 10895
KLLA0A03135g	Kluyveromyces lactis NRRL Y-1140
MGG_16276	Magnaporthe oryzae 70-15
NCU11234	Neurospora crassa OR74A
SPCC895.03c	Schizosaccharomyces pombe 972h-

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