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Gene Review

SUA7  -  Sua7p

Saccharomyces cerevisiae S288c

Synonyms: General transcription factor TFIIB, P9513.4, Transcription factor E, Transcription initiation factor IIB, YPR086W
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High impact information on SUA7


Biological context of SUA7


Associations of SUA7 with chemical compounds


Physical interactions of SUA7

  • Two portions of this carboxy-terminal region of Fcp1p bound directly to the first cyclin-like repeat in the core domain of the general transcription factor TFIIB, as well as to the RAP74 subunit of TFIIF [7].
  • Ino2 interacts physically with the basal transcription factor Sua7 (TFIIB of yeast) [8].

Other interactions of SUA7

  • However, in a SUA7+ background, ssu73-1 confers the same upstream shift at ADH1 as an rpb9 null allele [9].
  • SOH2 is identical to RPB2, which encodes the second largest subunit of RNA polymerase II, and SOH4 is the same as SUA7, encoding the yeast transcription initiation factor TFIIB [10].
  • Because mutations in SOH1, RPB2 and SUA7 suppress the hyperrecombination phenotype of hpr1 mutants, this suggests a link between recombination in direct repeats and transcription [10].
  • The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations [5].
  • Consistent with its role as a Sua7p import factor, deletion of KAP114 led to specific mislocalization of Sua7p to the cytoplasm [11].

Analytical, diagnostic and therapeutic context of SUA7


  1. The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. Pinto, I., Ware, D.E., Hampsey, M. Cell (1992) [Pubmed]
  2. Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae. Pappas, D.L., Hampsey, M. Mol. Cell. Biol. (2000) [Pubmed]
  3. The Kluyveromyces gene encoding the general transcription factor IIB: structural analysis and expression in Saccharomyces cerevisiae. Na, J.G., Hampsey, M. Nucleic Acids Res. (1993) [Pubmed]
  4. Protection against oxidative stress through SUA7/TFIIB regulation in Saccharomyces cerevisiae. Paes de Faria, J., Fernandes, L. Free Radic. Biol. Med. (2006) [Pubmed]
  5. The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations. Berroteran, R.W., Ware, D.E., Hampsey, M. Mol. Cell. Biol. (1994) [Pubmed]
  6. Evidence that transcription factor IIB is required for a post-assembly step in transcription initiation. Cho, E.J., Buratowski, S. J. Biol. Chem. (1999) [Pubmed]
  7. A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae. Kobor, M.S., Simon, L.D., Omichinski, J., Zhong, G., Archambault, J., Greenblatt, J. Mol. Cell. Biol. (2000) [Pubmed]
  8. TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae. Dietz, M., Heyken, W.T., Hoppen, J., Geburtig, S., Schüller, H.J. Mol. Microbiol. (2003) [Pubmed]
  9. Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae. Sun, Z.W., Tessmer, A., Hampsey, M. Nucleic Acids Res. (1996) [Pubmed]
  10. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae. Fan, H.Y., Cheng, K.K., Klein, H.L. Genetics (1996) [Pubmed]
  11. Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo-binding domains. Hodges, J.L., Leslie, J.H., Mosammaparast, N., Guo, Y., Shabanowitz, J., Hunt, D.F., Pemberton, L.F. Mol. Biol. Cell (2005) [Pubmed]
  12. Yeast RNA polymerase II initiation factor e: isolation and identification as the functional counterpart of human transcription factor IIB. Tschochner, H., Sayre, M.H., Flanagan, P.M., Feaver, W.J., Kornberg, R.D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB. Wu, W.H., Pinto, I., Chen, B.S., Hampsey, M. Genetics (1999) [Pubmed]
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