Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

MPS2 - Mps2p

Saccharomyces cerevisiae S288c

Synonyms: MMC1, Monopolar spindle protein 2, YGL075C

McBratney, S. et al., Winey, M. et al., Araki, Y. et al., Schramm, C. et al., Park, C.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on MPS2

This function in SPB duplication is probably fulfilled by a stable complex of Bbp1p and Mps2p, a nuclear envelope protein that is also essential for duplication plaque insertion [1].
MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication [2].
The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p [3].
Furthermore, Nbp1p is in the Mps2p-Bbp1p complex in the SPB [3].
In addition, Bbp1p, but likely not Mps2p, was required for proper localization of Cdc5p to the SPB [4].

Biological context of MPS2

Newly isolated mutations described here (mps1 and mps2, for monopolar spindle) similarly cause monopolar mitosis but their underlying effects on SPB duplication are unique [2].

Anatomical context of MPS2

Mutation of either the yeast MPS2 or the NDC1 gene leads to identical spindle pole body (SPB) duplication defects: The newly formed SPB is improperly inserted into the nuclear envelope (NE), preventing the cell from forming a bipolar mitotic spindle [5].

Other interactions of MPS2

The Mps2-1p mutant protein level is markedly reduced compared to wild-type Mps2p, and deletion of CUE1 restores the level of Mps2-1p to nearly wild-type levels [5].

References

The Bbp1p-Mps2p complex connects the SPB to the nuclear envelope and is essential for SPB duplication. Schramm, C., Elliott, S., Shevchenko, A., Schiebel, E. EMBO J. (2000) [Pubmed]
MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. Winey, M., Goetsch, L., Baum, P., Byers, B. J. Cell Biol. (1991) [Pubmed]
The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. Araki, Y., Lau, C.K., Maekawa, H., Jaspersen, S.L., Giddings, T.H., Schiebel, E., Winey, M. Mol. Biol. Cell (2006) [Pubmed]
Requirement for Bbp1p in the proper mitotic functions of Cdc5p in Saccharomyces cerevisiae. Park, C.J., Song, S., Giddings, T.H., Ro, H.S., Sakchaisri, K., Park, J.E., Seong, Y.S., Winey, M., Lee, K.S. Mol. Biol. Cell (2004) [Pubmed]
Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. McBratney, S., Winey, M. Genetics (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.