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Gene Review

CUE1  -  Cue1p

Saccharomyces cerevisiae S288c

Synonyms: Coupling of ubiquitin conjugation to ER degradation protein 1, KIS4, Kinetochore-defect suppressor 4, YM8156.06, YMR264W
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High impact information on CUE1

  • Here, a membrane-bound component of the ubiquitin system, Cue1p, was identified [1].
  • The region required for monoubiquitin binding mapped to the Vps9 CUE domain, a sequence previously identified by database searches as similar to parts of the yeast Cue1 and mammalian Tollip proteins [2].
  • Degradation further requires the activity of Cue1p-assembled Ubc7p, and its own catalytic site cysteine [3].
  • The Mps2-1p mutant protein level is markedly reduced compared to wild-type Mps2p, and deletion of CUE1 restores the level of Mps2-1p to nearly wild-type levels [4].
  • Cells lacking UBC7, CUE1, or DOA10 were cold sensitive, suggesting that these ERAD proteins have a role in cold adaptation, perhaps through effects on sterol biosynthesis [5].

Anatomical context of CUE1

  • Yeast strains lacking UBC7, CUE1, or DOA10 also assembled aberrant karmellae (ordered arrays of membranes surrounding the nucleus that assemble when HMGR is expressed at high levels) [5].

Physical interactions of CUE1


Other interactions of CUE1

  • Cue1p has been shown to recruit the soluble ubiquitin-conjugating enzyme, Ubc7p, to the cytoplasmic face of the ER membrane where it can ubiquitinate its substrates and target them for degradation by the proteasome [4].


  1. Role of Cue1p in ubiquitination and degradation at the ER surface. Biederer, T., Volkwein, C., Sommer, T. Science (1997) [Pubmed]
  2. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. Shih, S.C., Prag, G., Francis, S.A., Sutanto, M.A., Hurley, J.H., Hicke, L. EMBO J. (2003) [Pubmed]
  3. Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. Walter, J., Urban, J., Volkwein, C., Sommer, T. EMBO J. (2001) [Pubmed]
  4. Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. McBratney, S., Winey, M. Genetics (2002) [Pubmed]
  5. Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae. Loertscher, J., Larson, L.L., Matson, C.K., Parrish, M.L., Felthauser, A., Sturm, A., Tachibana, C., Bard, M., Wright, R. Eukaryotic Cell (2006) [Pubmed]
  6. A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation. Kostova, Z., Mariano, J., Scholz, S., Koenig, C., Weissman, A.M. J. Cell. Sci. (2009) [Pubmed]
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