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Gene Review:

NBP1 - Nbp1p

Saccharomyces cerevisiae S288c

Synonyms: L9122.6, NAP1-binding protein, YLR457C

Araki, Y. et al., Ohkuni, K. et al., Shimizu, Y. et al.

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High impact information on NBP1

Furthermore, Nbp1p is in the Mps2p-Bbp1p complex in the SPB [1].
These results demonstrate that Nbp1p is a SPB component that acts in SPB duplication at the point of SPB insertion into the nuclear envelope [1].
Nbp2p is a Nap1-binding protein in Saccharomyces cerevisiae identified by its interaction with Nap1 by a two-hybrid system [2].
Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity [2].
NBP1 is an essential gene and encodes a novel protein consisting of 319 amino acids, with a coiled-coil structure in the center of the predicted amino acid sequence [3].

Analytical, diagnostic and therapeutic context of NBP1

Immunoelectron microscopy confirmed that Nbp1p localizes to the SPB, suggesting a function at this location [1].

References

The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. Araki, Y., Lau, C.K., Maekawa, H., Jaspersen, S.L., Giddings, T.H., Schiebel, E., Winey, M. Mol. Biol. Cell (2006) [Pubmed]
Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity. Ohkuni, K., Okuda, A., Kikuchi, A. Genetics (2003) [Pubmed]
NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localization. Shimizu, Y., Akashi, T., Okuda, A., Kikuchi, A., Fukui, K. Gene (2000) [Pubmed]

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