Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ATE1 - Ate1p

Saccharomyces cerevisiae S288c

Synonyms: Arginine-tRNA--protein transferase 1, Arginyl-tRNA--protein transferase 1, Arginyltransferase 1, R-transferase 1, YGL017W

Rai, R. et al., Balzi, E. et al., Capieaux, E. et al., Li, J. et al., Barker, C.R. et al.

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Disease relevance of ATE1

Expression of the yeast ATE1 gene in Escherichia coli, which lacks Arg-transferases, was used to show that the ATE1 protein possesses the Arg-transferase activity [1].

High impact information on ATE1

This finding provides insights into the significance of Cys-specific protein arginylation in mammals and suggests possibilities of the determinants of substrate specificity within the ATE1 molecule [2].
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site [3].
We also propose a previously unidentified role for Ate1 in modulating the level of topoisomerase II through the cell cycle [4].
Physical, transcriptional and genetical mapping of a 24 kb DNA fragment located between the PMA1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae [5].

References

Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae. Balzi, E., Choder, M., Chen, W.N., Varshavsky, A., Goffeau, A. J. Biol. Chem. (1990) [Pubmed]
Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. Rai, R., Kashina, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site. Li, J., Pickart, C.M. Biochemistry (1995) [Pubmed]
The identification and characterisation of a functional interaction between arginyl-tRNA-protein transferase and topoisomerase II. Barker, C.R., Mouchel, N.A., Jenkins, J.R. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Physical, transcriptional and genetical mapping of a 24 kb DNA fragment located between the PMA1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae. Capieaux, E., Ulaszewski, S., Balzi, E., Goffeau, A. Yeast (1991) [Pubmed]

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