The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

MTL1  -  Mtl1p

Saccharomyces cerevisiae S288c

Synonyms: MID two-like protein 1, Protein MTL1, YGR023W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on MTL1

  • We identified C. glabrata MTL1 as the ortholog of the MAT locus of K. delphensis and show that switching between C. glabrata MTL1a and MTL1alpha genotypes occurs in vivo [1].
  • Finally, we identified a yeast homolog of MID2, designated MTL1, which provides a partially redundant function with MID2 for cell integrity signaling during vegetative growth at elevated temperature but not for survival of pheromone treatment [2].
  • Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress [3].
  • Mtl1 is characterized for the first time as a cell-wall sensor of oxidative stress [3].
 

Biological context of MTL1

  • In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p [4].

References

  1. Evolution of the MAT locus and its Ho endonuclease in yeast species. Butler, G., Kenny, C., Fagan, A., Kurischko, C., Gaillardin, C., Wolfe, K.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel, M., Philip, B., Buehrer, B.M., Errede, B., Levin, D.E. Mol. Cell. Biol. (1999) [Pubmed]
  3. Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. Vilella, F., Herrero, E., Torres, J., de la Torre-Ruiz, M.A. J. Biol. Chem. (2005) [Pubmed]
  4. Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. Ketela, T., Green, R., Bussey, H. J. Bacteriol. (1999) [Pubmed]
 
WikiGenes - Universities