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Gene Review:

MTL1 - Mtl1p

Saccharomyces cerevisiae S288c

Synonyms: MID two-like protein 1, Protein MTL1, YGR023W

Butler, G. et al., Vilella, F. et al., Rajavel, M. et al., Ketela, T. et al.

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High impact information on MTL1

We identified C. glabrata MTL1 as the ortholog of the MAT locus of K. delphensis and show that switching between C. glabrata MTL1a and MTL1alpha genotypes occurs in vivo [1].
Finally, we identified a yeast homolog of MID2, designated MTL1, which provides a partially redundant function with MID2 for cell integrity signaling during vegetative growth at elevated temperature but not for survival of pheromone treatment [2].
Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress [3].
Mtl1 is characterized for the first time as a cell-wall sensor of oxidative stress [3].

Biological context of MTL1

In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p [4].

References

Evolution of the MAT locus and its Ho endonuclease in yeast species. Butler, G., Kenny, C., Fagan, A., Kurischko, C., Gaillardin, C., Wolfe, K.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel, M., Philip, B., Buehrer, B.M., Errede, B., Levin, D.E. Mol. Cell. Biol. (1999) [Pubmed]
Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. Vilella, F., Herrero, E., Torres, J., de la Torre-Ruiz, M.A. J. Biol. Chem. (2005) [Pubmed]
Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. Ketela, T., Green, R., Bussey, H. J. Bacteriol. (1999) [Pubmed]

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