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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PAC10  -  Pac10p

Saccharomyces cerevisiae S288c

Synonyms: GIM2, Genes involved in microtubule biogenesis protein 2, Gim complex subunit 2, GimC subunit 2, PFD3, ...
 
 
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High impact information on PAC10

  • Reconstitution experiments with MtGimC suggest that two subunits of the alpha class (archaeal Gimalpha and eukaryotic Gim2 and 5) form a dimer onto which four subunits of the beta class (archaeal Gimbeta and eukaryotic Gim1, 3, 4 and 6) assemble [1].
  • Importantly, plp1Delta cells that also lack Pac10, a component of the GimC/PFD complex, are even less affected by free beta-tubulin [2].
  • Conversely, overexpression of Pac10p enhances the ability of alpha-tubulin or Rbl2p to suppress the lethality associated with excess beta-tubulin [3].
  • However, Pac10p is itself not a beta-tubulin binding protein [3].
  • The results suggest that Pac10p modulates the level of alpha-tubulin in the cell, and so influences microtubule morphogenesis and tubulin metabolism [3].
 

Anatomical context of PAC10

 

Other interactions of PAC10

  • Three of these proteins, Cac2p, Pac10p, and Swc7p, were identified as true NatB substrates [4].

References

  1. MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin. Leroux, M.R., Fändrich, M., Klunker, D., Siegers, K., Lupas, A.N., Brown, J.R., Schiebel, E., Dobson, C.M., Hartl, F.U. EMBO J. (1999) [Pubmed]
  2. A novel step in beta-tubulin folding is important for heterodimer formation in Saccharomyces cerevisiae. Lacefield, S., Solomon, F. Genetics (2003) [Pubmed]
  3. Modulation of tubulin polypeptide ratios by the yeast protein Pac10p. Alvarez, P., Smith, A., Fleming, J., Solomon, F. Genetics (1998) [Pubmed]
  4. Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Caesar, R., Warringer, J., Blomberg, A. Eukaryotic Cell (2006) [Pubmed]
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