The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

CAC2  -  Cac2p

Saccharomyces cerevisiae S288c

Synonyms: CAF-1 60 kDa subunit, Chromatin assembly factor 1 subunit p60, YML102W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on CAC2

  • Loss of the other CAF-I subunits (Cac2p and Cac3p/Msi1p) also results in the shmoo cluster phenotype, implying that loss of CAF-I activity gives rise to this unstable repression of HML [1].
  • We also observed a weak interaction between Asf1p and Cac2p in vitro, and we hypothesize that this interaction underlies the functional synergy between these histone deposition proteins [2].
  • We investigated this mechanism and found that CAC3 suppression of RAS/cAMP signal transduction was independent of either CAC1 or CAC2, subunits required for CAF-I function [3].
  • Three of these proteins, Cac2p, Pac10p, and Swc7p, were identified as true NatB substrates [4].

References

  1. Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Enomoto, S., Berman, J. Genes Dev. (1998) [Pubmed]
  2. Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing. Krawitz, D.C., Kama, T., Kaufman, P.D. Mol. Cell. Biol. (2002) [Pubmed]
  3. CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1. Johnston, S.D., Enomoto, S., Schneper, L., McClellan, M.C., Twu, F., Montgomery, N.D., Haney, S.A., Broach, J.R., Berman, J. Mol. Cell. Biol. (2001) [Pubmed]
  4. Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Caesar, R., Warringer, J., Blomberg, A. Eukaryotic Cell (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities