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Gene Review:

GTO1 - Gto1p

Saccharomyces cerevisiae S288c

Synonyms: G6664, Glutathione S-transferase omega-like 1, Glutathione-dependent dehydroascorbate reductase, YGR154C

Barreto, L. et al., Skala, J. et al.

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High impact information on GTO1

G6664 shares significant homology with the ORF YKR076w from chromosome XI [1].
Diamide and 1-chloro-2,4-dinitrobenzene (causing depletion of reduced glutathione) also induce expression of GTO1 over basal levels [2].
The role of Gto1 at the S. cerevisiae peroxisomes could be related to the redox regulation of the Str3 cystathionine beta-lyase protein [2].
A gto1-null mutant also shows growth defects on oleic acid-based medium, which is indicative of abnormal peroxisomal functions, and altered expression of genes related to sulfur amino acid metabolism [2].
Phenotypic analyses with single and multiple mutants in the S. cerevisiae glutathione transferase genes show that, in the absence of Gto1 and the two Gtt proteins, cells display increased sensitivity to cadmium [2].

References

The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames. Skala, J., Nawrocki, A., Goffeau, A. Yeast (1995) [Pubmed]
A Peroxisomal Glutathione Transferase of Saccharomyces cerevisiae Is Functionally Related to Sulfur Amino Acid Metabolism. Barreto, L., Garcer??, A., Jansson, K., Sunnerhagen, P., Herrero, E. Eukaryotic Cell (2006) [Pubmed]

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