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Gene Review

PTI1  -  Pti1p

Saccharomyces cerevisiae S288c

Synonyms: G6670, Protein PTI1, YGR156W
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High impact information on PTI1

  • A genetic screen for suppressors of loss of yeast CTD kinase I (CTDK-I) function (by deletion of the catalytic subunit gene CTK1) identified PTI1, a potential 3' cleavage/polyadenylation factor [1].
  • Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation [2].
  • We also provide evidence that Pti1p probably acts by uncoupling cleavage and polyadenylation, and functions in coordination with the Nrd1p-dependent pathway for 3' end formation of non-polyadenylated transcripts [2].
  • In addition, the pto kinase phosphorylates a previously characterized substrate of Pto, the Pto-interacting Pti1 serine/threonine kinase [3].


  1. The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Skaar, D.A., Greenleaf, A.L. Mol. Cell (2002) [Pubmed]
  2. Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. Dheur, S., Vo, l.e. .T.A., Voisinet-Hakil, F., Minet, M., Schmitter, J.M., Lacroute, F., Wyers, F., Minvielle-Sebastia, L. EMBO J. (2003) [Pubmed]
  3. Alleles of Pto and Fen occur in bacterial speck-susceptible and fenthion-insensitive tomato cultivars and encode active protein kinases. Jia, Y., Loh, Y.T., Zhou, J., Martin, G.B. Plant Cell (1997) [Pubmed]
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