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Gene Review:

CRH1 - Crh1p

Saccharomyces cerevisiae S288c

Synonyms: Congo red hypersensitive protein 1, G7553, YGR189C

Rodríguez-Peña, J.M. et al., Arroyo, J. et al.

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Disease relevance of CRH1

By site-directed mutagenesis we found that the putative glycosidase domain of CRH1 was critical for its function in complementing hypersensitivity to the inhibitors [1].

High impact information on CRH1

These genes were renamed CRH1 and CRH2, respectively, for Congo red hypersensitive [1].

Biological context of CRH1

One of the ORFs, G7553, shares significant homologies with the gene UTR2 from S. cerevisiae [2].

Anatomical context of CRH1

The involvement of CRH1 and CRH2 in the development of cell wall architecture was clearly shown, since the alkali-soluble glucan fraction in the crh1Delta crh2Delta strain was almost twice the level in the wild-type [1].

Other interactions of CRH1

Crh1 and Crh2 are localized at the cell surface, particularly in chitin-rich areas [1].

References

A novel family of cell wall-related proteins regulated differently during the yeast life cycle. Rodríguez-Peña, J.M., Cid, V.J., Arroyo, J., Nombela, C. Mol. Cell. Biol. (2000) [Pubmed]
DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo, J., García-Gonzalez, M., García-Saez, M.I., Sanchez, M., Nombela, C. Yeast (1997) [Pubmed]

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