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Gene Review

UTR2  -  Utr2p

Saccharomyces cerevisiae S288c

Synonyms: CRH2, Congo red hypersensitive protein 2, SYGP-ORF18, YEL040W
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High impact information on UTR2

  • These genes were renamed CRH1 and CRH2, respectively, for Congo red hypersensitive [1].
  • Crh2 was found to localize mainly at the bud neck throughout the whole budding cycle, in mating projections and zygotes, but not in ascospores [1].
  • Crh2p is localised at the mother-bud neck in bud1 cells following the random budding pattern characteristic of this mutant [2].
  • The Crh2p distribution was greatly altered in a cdc42-1 mutant, indicating complete dependence on an organised actin cytoskeleton for polarised Crh2p distribution [2].
  • Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites [2].

Biological context of UTR2


Anatomical context of UTR2

  • The involvement of CRH1 and CRH2 in the development of cell wall architecture was clearly shown, since the alkali-soluble glucan fraction in the crh1Delta crh2Delta strain was almost twice the level in the wild-type [1].

Other interactions of UTR2

  • Crh1 and Crh2 are localized at the cell surface, particularly in chitin-rich areas [1].


  1. A novel family of cell wall-related proteins regulated differently during the yeast life cycle. Rodríguez-Peña, J.M., Cid, V.J., Arroyo, J., Nombela, C. Mol. Cell. Biol. (2000) [Pubmed]
  2. Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites. Rodriguez-Peña, J.M., Rodriguez, C., Alvarez, A., Nombela, C., Arroyo, J. J. Cell. Sci. (2002) [Pubmed]
  3. DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo, J., García-Gonzalez, M., García-Saez, M.I., Sanchez, M., Nombela, C. Yeast (1997) [Pubmed]
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