High impact information on UTR2

• These genes were renamed CRH1 and CRH2, respectively, for Congo red hypersensitive [1].
• Crh2 was found to localize mainly at the bud neck throughout the whole budding cycle, in mating projections and zygotes, but not in ascospores [1].
• Crh2p is localised at the mother-bud neck in bud1 cells following the random budding pattern characteristic of this mutant [2].
• The Crh2p distribution was greatly altered in a cdc42-1 mutant, indicating complete dependence on an organised actin cytoskeleton for polarised Crh2p distribution [2].
• Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites [2].

Biological context of UTR2

• One of the ORFs, G7553, shares significant homologies with the gene UTR2 from S. cerevisiae [3].
• Crh2p distribution was studied in several genetic backgrounds affected in different steps of the cell polarity establishment machinery or/and bud morphogenesis [2].

Anatomical context of UTR2

• The involvement of CRH1 and CRH2 in the development of cell wall architecture was clearly shown, since the alkali-soluble glucan fraction in the crh1Delta crh2Delta strain was almost twice the level in the wild-type [1].

Other interactions of UTR2

• Crh1 and Crh2 are localized at the cell surface, particularly in chitin-rich areas [1].

References