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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPIL4  -  peptidylprolyl isomerase (cyclophilin)-like 4

Homo sapiens

Synonyms: Cyclophilin-like protein PPIL4, PPIase, Peptidyl-prolyl cis-trans isomerase-like 4, Rotamase PPIL4
 
 
 
 
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High impact information on PPIL4

  • According to bioinformatics analysis, the PPIL4 gene was found to be located in chromosome 6q24-->q25 [1].
  • Here we report that a novel member of the cyclophilin family, PPIL4, was cloned and identified during the large-scale sequencing analysis from a human fetal brain cDNA library [1].
  • Besides the PPIase motif, PPIL4 also has an RNA recognition motif (RRM), a pair of bipartite nuclear targeting sequences, and a lysine rich domain [1].
  • RT-PCR analysis indicated that PPIL4 gene expression is abundant in kidney but has a ubiquitously low expression pattern in other human adult tissues [1].
 

Analytical, diagnostic and therapeutic context of PPIL4

  • Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain [1].

References

  1. Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain. Zeng, L., Zhou, Z., Xu, J., Zhao, W., Wang, W., Huang, Y., Cheng, C., Xu, M., Xie, Y., Mao, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
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