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Gene Review

ATG27  -  Atg27p

Saccharomyces cerevisiae S288c

Synonyms: Autophagy-related protein 27, ETF1, Enhancer of VPS34 missorting protein 1, J0490, YJL178C
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High impact information on ATG27

  • Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy [1].
  • Although Etf1 does not contain a known 3-phosphoinositide-binding domain (i.e., FYVE or Phox), we find that Etf1 interacts with PtdIns(3)P and that this interaction requires a basic amino acid motif (KKPAKK) within the cytosolic region of the protein [1].
  • Here, we characterize a second transmembrane protein Atg27 that is required for specific autophagy in yeast [2].
  • Atg27 is required for Atg9 cycling and shuttles between the pre-autophagosomal structure, mitochondria, and the Golgi complex [2].
  • In this addendum, we discuss the trafficking of Atg27 in yeast and compare it with that of Atg9, and consider the possible meaning of Atg27 Golgi localization [3].

Biological context of ATG27

  • We propose that Vps34 regulates the CPY, Cvt, and macroautophagy pathways through distinct sets of PtdIns(3)P-binding effectors and that Vps34 promotes protein trafficking in the Cvt pathway through activation/localization of the effector protein Etf1 [1].

Anatomical context of ATG27


  1. Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. Wurmser, A.E., Emr, S.D. J. Cell Biol. (2002) [Pubmed]
  2. Atg27 Is Required for Autophagy-dependent Cycling of Atg9. Yen, W.L., Legakis, J.E., Nair, U., Klionsky, D.J. Mol. Biol. Cell (2007) [Pubmed]
  3. Atg27 is a Second Transmembrane Cycling Protein. Yen, W.L., Klionsky, D.J. Autophagy (2007) [Pubmed]
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