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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

YUR1  -  mannosyltransferase YUR1

Saccharomyces cerevisiae S288c

Synonyms: J0657, YJL139C
 
 
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High impact information on YUR1

  • We have carried out a functional analysis of Ktr1p, Ktr2p, and Yur1p [1].
  • A cluster of six genes within 10 kb (YUR1, TIF2, two new ORFs, an RSP25 homologue and MRS3) have homologues arranged similarly within 28.5 kb on the right arm of chromosome XI [2].
 

Biological context of YUR1

  • Examination of the electrophoretic mobility of the N-linked modified protein invertase in null mutant strains indicates that Ktr1p, Ktr2p, and Yur1p are involved in N-linked glycosylation, possibly as redundant enzymes [1].
  • We identified two other genes, YUR1 on chromosome 10, and KTR1 on chromosome 15, whose predicted products share 36% identity with Kre2p over more than 300 amino acid residues [3].

References

  1. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier, M., Sdicu, A.M., Camirand, A., Bussey, H. J. Biol. Chem. (1996) [Pubmed]
  2. Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI. Katsoulou, C., Tzermia, M., Tavernarakis, N., Alexandraki, D. Yeast (1996) [Pubmed]
  3. Yeast KRE2 defines a new gene family encoding probable secretory proteins, and is required for the correct N-glycosylation of proteins. Hill, K., Boone, C., Goebl, M., Puccia, R., Sdicu, A.M., Bussey, H. Genetics (1992) [Pubmed]
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