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Gene Review

MRS3  -  Mrs3p

Saccharomyces cerevisiae S288c

Synonyms: J0675, Mitochondrial RNA-splicing protein MRS3, YJL133W
 
 
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Disease relevance of MRS3

 

High impact information on MRS3

 

Biological context of MRS3

  • Deletion of the yeast frataxin homolog (YFH1) was combined with deletions of MRS3 and MRS4, mitochondrial carrier proteins implicated in iron homeostasis [5].
  • MRS3 and MRS4, the genes for two mitochondrial-solute carrier proteins, can suppress both phenotypes when present in high-copy-number plasmids [6].
  • In order to search for further multicopy suppressors of the mrs2-1 mutant phenotype, an yeast genomic DNA library, MW90, was constructed in YEp351 from a strain deleted for the MRS2, MRS3 and MRS4 genes [6].
  • Nuclear suppression of a mitochondrial RNA splice defect: nucleotide sequence and disruption of the MRS3 gene [7].
  • Genetic mapping confirms that the MRS3 gene is 2 cM distal to the URA2 gene on the right arm of chromosome X [8].
 

Anatomical context of MRS3

  • The Mrs3/4p carriers were required for rapid iron transport into mitochondria for heme synthesis, whereas there was also evidence for an alternative slower system [5].
  • Northern blot analyses showed that Mrs3/4 is ubiquitously expressed as a 1.8-kb transcript with a relative abundance in the heart, liver, kidney, and testis [9].
 

Associations of MRS3 with chemical compounds

  • We sequenced the oxy1 and frr1 alleles of MRS3/4 and found that the frr1 mutation results in a premature stop codon, while the oxy1 mutation results in the substitution of a highly conserved glutamate residue with lysine [10].
 

Other interactions of MRS3

  • Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis [5].
 

Analytical, diagnostic and therapeutic context of MRS3

  • Sequence analysis of the 5' end of dl9 indicated that this duplicated sequence was inserted within the intergenic region close to the MRS3 gene and was transcribed from an unknown promoter divergently from the MRS3 gene [8].

References

  1. cDNAs from Onchocerca sp. encoding members of the MRS3/MRS4 class of mitochondrial solute carriers. Catmull, J., Miller, D.J. Biochim. Biophys. Acta (1996) [Pubmed]
  2. Mrs3p, mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria. Zhang, Y., Lyver, E.R., Knight, S.A., Pain, D., Lesuisse, E., Dancis, A. J. Biol. Chem. (2006) [Pubmed]
  3. A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. Mühlenhoff, U., Stadler, J.A., Richhardt, N., Seubert, A., Eickhorst, T., Schweyen, R.J., Lill, R., Wiesenberger, G. J. Biol. Chem. (2003) [Pubmed]
  4. MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. Wiesenberger, G., Link, T.A., von Ahsen, U., Waldherr, M., Schweyen, R.J. J. Mol. Biol. (1991) [Pubmed]
  5. Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis. Zhang, Y., Lyver, E.R., Knight, S.A., Lesuisse, E., Dancis, A. J. Biol. Chem. (2005) [Pubmed]
  6. A multitude of suppressors of group II intron-splicing defects in yeast. Waldherr, M., Ragnini, A., Jank, B., Teply, R., Wiesenberger, G., Schweyen, R.J. Curr. Genet. (1993) [Pubmed]
  7. Nuclear suppression of a mitochondrial RNA splice defect: nucleotide sequence and disruption of the MRS3 gene. Schmidt, C., Söllner, T., Schweyen, R.J. Mol. Gen. Genet. (1987) [Pubmed]
  8. Recovery of gene function by gene duplication in Saccharomyces cerevisiae. Bach, M.L., Roelants, F., De Montigny, J., Huang, M., Potier, S., Souciet, J.L. Yeast (1995) [Pubmed]
  9. Characterization of a putative murine mitochondrial transporter homology of hMRS3/4. Li, F.Y., Leibiger, B., Leibiger, I., Larsson, C. Mamm. Genome (2002) [Pubmed]
  10. Role of mitochondrial carrier protein Mrs3/4 in iron acquisition and oxidative stress resistance of Cryptococcus neoformans. Nyhus, K.J., Ozaki, L.S., Jacobson, E.S. Med. Mycol. (2002) [Pubmed]
 
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