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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KTR2  -  mannosyltransferase KTR2

Saccharomyces cerevisiae S288c

Synonyms: YKR061W
 
 
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High impact information on KTR2

  • Examination of the electrophoretic mobility of the N-linked modified protein invertase in null mutant strains indicates that Ktr1p, Ktr2p, and Yur1p are involved in N-linked glycosylation, possibly as redundant enzymes [1].
  • KTR2: a new member of the KRE2 mannosyltransferase gene family [2].
  • A null mutation in KTR2 leads to partial resistance to killer toxin and hints that KTR2, which encodes a putative mannosyltransferase, is involved in extracellular matrix assembly [2].
  • In contrast to KRE2 null mutants, which produce shortened (two-mannose) chains, mutants harboring a KTR2 gene disruption synthesize O-linked chains with the wild-type patterns of five mannose residues [2].

References

  1. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier, M., Sdicu, A.M., Camirand, A., Bussey, H. J. Biol. Chem. (1996) [Pubmed]
  2. KTR2: a new member of the KRE2 mannosyltransferase gene family. Lussier, M., Camirand, A., Sdicu, A.M., Bussey, H. Yeast (1993) [Pubmed]
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