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Gene Review

KTR1  -  alpha-1,2-mannosyltransferase KTR1

Saccharomyces cerevisiae S288c

Synonyms: Alpha-1,2 mannosyltransferase KTR1, YOR099W, YOR3189W
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High impact information on KTR1

  • Determination of the mobility of the specifically N-linked glycoprotein invertase in different null strains indicates that Ktr1p, Ktr3p, and Kre2p are also jointly involved in N-linked glycosylation, possibly in establishing some of the outer chain alpha1,2-linkages [1].
  • We have determined a role for Ktr1p and Ktr3p as mannosyltransferases in the synthesis of the carbohydrate chains attached to Saccharomyces cerevisiae O- and N-modified proteins [1].
  • We have carried out a functional analysis of Ktr1p, Ktr2p, and Yur1p [2].
  • The enzymes have an absolute requirement for Mn2+ and a similar K(m) for mannose (280-350 mM), methyl-alpha-mannoside (60-90 mM) and GDP-mannose (50-90 microM), but the Vmax was approx. 10 times higher for Kre2p/Mnt1p than for Ktr1p [3].

Biological context of KTR1

  • We identified two other genes, YUR1 on chromosome 10, and KTR1 on chromosome 15, whose predicted products share 36% identity with Kre2p over more than 300 amino acid residues [4].

Associations of KTR1 with chemical compounds

  • After induction with methanol, the medium contained approx, 40 and 400 mg/l of soluble recombinant Kre2p/Mnt1p and Ktr1p respectively [3].

Other interactions of KTR1


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