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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DLS1  -  Dls1p

Saccharomyces cerevisiae S288c

Synonyms: DPB3-like subunit of ISW2 complex 1, HRD167, J1115, Protein DLS1, YJL065C
 
 
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High impact information on DLS1

  • Transcriptional analyses reveal that the Isw2 complex requires Dls1p to various degrees at a wide variety of loci in vivo [1].
  • Both proteins, Dpb4p and Yjl065cp (named Dls1p), contain histone fold motifs and are homologous to the two smallest subunits of ISWI-containing CHRAC complexes in higher eukaryotes [1].
  • Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo [1].
  • We also showed using a transient expression assay system, that the dls1 mutation results in a decreased degradation of proteins with Asp or Glu at their N-termini, and that the introduction of the wild-type AtATE1 gene reverses this deficiency [2].
  • Leaf senescence progresses more slowly in the dls1 mutant than in the wild-type plant in both age-dependent and dark-induced senescence [2].
 

Biological context of DLS1

  • Introduction of a wild-type AtATE1 gene into the dls1 mutant complemented the dls1 phenotype [2].
 

Analytical, diagnostic and therapeutic context of DLS1

  • AtATE1 transcripts were not detectable in the dls1 mutant by RT-PCR analysis [2].

References

  1. Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo. McConnell, A.D., Gelbart, M.E., Tsukiyama, T. Mol. Cell. Biol. (2004) [Pubmed]
  2. A delayed leaf senescence mutant is defective in arginyl-tRNA:protein arginyltransferase, a component of the N-end rule pathway in Arabidopsis. Yoshida, S., Ito, M., Callis, J., Nishida, I., Watanabe, A. Plant J. (2002) [Pubmed]
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