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Gene Review:

RTT101 - cullin RTT101

Saccharomyces cerevisiae S288c

Synonyms: CUL8, Cullin-8, Cullin-C, J1166, Regulator of Ty1 transposition protein 101, ...

Michel, J.J. et al., Scholes, D.T. et al., Baldwin, E.L. et al.

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High impact information on RTT101

Whereas null mutants of CUL3 appear normal, yeast cells lacking CUL8 have a slower growth rate and are delayed in their progress through anaphase [1].
Deletion of the RAD9 gene suppressed the anaphase delay phenotype of cul8delta, suggesting that loss of Cul8 function may compromise genomic integrity [1].
A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression [1].
These results indicate that in addition to the anaphase promoting complex, mitotic progression may involve another E3 ubiquitin ligase mediated by Cul8 protein [1].
Mutations in RTT101 and NUT2 dramatically stimulated Ty1 integration upstream of tRNA genes [2].

Biological context of RTT101

MMS22 is epistatic with RTT101 and RTT107, genes that encode its protein binding partners [3].

References

A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. Michel, J.J., McCarville, J.F., Xiong, Y. J. Biol. Chem. (2003) [Pubmed]
Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Scholes, D.T., Banerjee, M., Bowen, B., Curcio, M.J. Genetics (2001) [Pubmed]
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Baldwin, E.L., Berger, A.C., Corbett, A.H., Osheroff, N. Nucleic Acids Res. (2005) [Pubmed]

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