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Gene Review

CUL3  -  cullin CUL3

Saccharomyces cerevisiae S288c

Synonyms: Cullin-3, Cullin-B, YGR003W
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High impact information on CUL3

  • We show here that S. pombe CUL3 (Pcu3p) forms a complex with the RING protein Pip1p and all three BTB/POZ domain proteins encoded in the fission yeast genome [1].
  • CONCLUSIONS: Our results suggest that MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism [2].
  • Whereas null mutants of CUL3 appear normal, yeast cells lacking CUL8 have a slower growth rate and are delayed in their progress through anaphase [3].
  • CUL3 was coimmunoprecipated with KLHL10, and KLHL10 was also detected in the CUL3 immunoprecipitants using testis lysates [4].
  • CUL3 protein was detected in elongating and elongated spermatids (steps 10-16) by immunofluorescent microscopy [4].

Biological context of CUL3

  • These findings suggest that KLHL10, like other BTB/kelch proteins, interacts with CUL3 to form a CUL3-based ubiquitin E3 ligase that functions specifically in the testis to mediate protein ubiquitination during spermiogenesis [4].

Associations of CUL3 with chemical compounds

  • All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue [5].

Other interactions of CUL3


Analytical, diagnostic and therapeutic context of CUL3

  • In a search for KLHL10-interacting proteins using a yeast two-hybrid assay, we identified Cullin3 (CUL3) as one of multiple KLHL10-interacting partners [4].
  • RESULTS: Here, we show that MEL-26, a substrate-specific adaptor of the CUL-3-based E3 ligase, is required for efficient cell separation and cleavage furrow ingression during the C. elegans early mitotic divisions [2].


  1. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Geyer, R., Wee, S., Anderson, S., Yates, J., Wolf, D.A. Mol. Cell (2003) [Pubmed]
  2. The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism. Luke-Glaser, S., Pintard, L., Lu, C., Mains, P.E., Peter, M. Curr. Biol. (2005) [Pubmed]
  3. A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. Michel, J.J., McCarville, J.F., Xiong, Y. J. Biol. Chem. (2003) [Pubmed]
  4. Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. Wang, S., Zheng, H., Esaki, Y., Kelly, F., Yan, W. Biol. Reprod. (2006) [Pubmed]
  5. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Laplaza, J.M., Bostick, M., Scholes, D.T., Curcio, M.J., Callis, J. Biochem. J. (2004) [Pubmed]
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