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Gene Review

RTT107  -  Rtt107p

Saccharomyces cerevisiae S288c

Synonyms: ESC4, Establishes silent chromatin protein 4, Regulator of Ty1 transposition protein 107, YHR154W
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Disease relevance of RTT107


High impact information on RTT107

  • Here it is reported that Esc4p is phosphorylated by Mec1p in response to DNA damage during DNA replication and that cells lacking Esc4p are hypersensitive to DNA damage specifically during S phase [1].
  • Esc4p is not required for the intra-S-phase checkpoint but is essential for resumption of chromosome replication after DNA damage, and its role in promoting restart appears to be distinct from that of Rad53p [1].
  • Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4 [2].
  • However, the function of Esc4 does not appear to be restricted to a Rad55-dependent process, as we observed an increase in sensitivity to the DNA alkylating agent methane methylsulfonate (MMS) in a esc4Deltarad55Delta mutant, as well as in double mutants of esc4Delta and other recombination genes, compared to the corresponding single mutants [3].
  • CONCLUSION: Rtt107/Esc4 binds to the silencing protein Sir3 and the DNA repair protein Slx4 via different BRCT motifs, thus providing a bridge linking silent chromatin to DNA repair enzymes [4].

Biological context of RTT107


Associations of RTT107 with chemical compounds


Physical interactions of RTT107

  • A two-hybrid screen showed that the N-terminal BRCT motifs of Rtt107/Esc4 bound to Slx4, a protein previously shown to be involved in DNA repair and required for viability in a strain lacking the DNA helicase Sgs1 [4].

Other interactions of RTT107

  • These results identify Esc4p as an important new S-phase-specific target of Mec1p [1].


  1. Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. Rouse, J. EMBO J. (2004) [Pubmed]
  2. Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Roberts, T.M., Kobor, M.S., Bastin-Shanower, S.A., Ii, M., Horte, S.A., Gin, J.W., Emili, A., Rine, J., Brill, S.J., Brown, G.W. Mol. Biol. Cell (2006) [Pubmed]
  3. Esc4/Rtt107 and the control of recombination during replication. Chin, J.K., Bashkirov, V.I., Heyer, W.D., Romesberg, F.E. DNA Repair (Amst.) (2006) [Pubmed]
  4. Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs. Zappulla, D.C., Maharaj, A.S., Connelly, J.J., Jockusch, R.A., Sternglanz, R. BMC Mol. Biol. (2006) [Pubmed]
  5. Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Baldwin, E.L., Berger, A.C., Corbett, A.H., Osheroff, N. Nucleic Acids Res. (2005) [Pubmed]
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