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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RPS5  -  ribosomal 40S subunit protein S5

Saccharomyces cerevisiae S288c

Synonyms: 40S ribosomal protein S5, J2045, RP14, RPS2, S2, ...
 
 
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High impact information on RPS5

  • Surprisingly, the RPS5 core promoter can be activated by various activation domains fused to a GAL4 DNA binding domain, but not by the original upstream activating sequence (UAS) of the RPS5 gene [1].
  • Requirement for yeast TAF145 function in transcriptional activation of the RPS5 promoter that depends on both core promoter structure and upstream activating sequences [1].
  • Here, we show in these mutants that the transcription of the RPS5 gene is impaired, mostly due to a defect in transcriptional activation rather than to a defect in core promoter recognition, although the latter is slightly affected as well [1].
  • We also show that RPS5 acts on the SUC1 and SUC4 genes but not on SUC2 and SUC3, which are members of the SUC family [2].
  • Phenotype traits associated with different alleles at the RPS5 locus in Saccharomyces cerevisiae [2].
 

Biological context of RPS5

  • We suggest that genes similar RPS5 are responsible for the low levels of invertase activity observed in diploid strains of S. cerevisiae [3].

References

  1. Requirement for yeast TAF145 function in transcriptional activation of the RPS5 promoter that depends on both core promoter structure and upstream activating sequences. Tsukihashi, Y., Kawaichi, M., Kokubo, T. J. Biol. Chem. (2001) [Pubmed]
  2. Phenotype traits associated with different alleles at the RPS5 locus in Saccharomyces cerevisiae. Valentín, E., Zueco, J., Nieto, A., Sentandreu, R., del Castillo Agudo, L. Curr. Genet. (1992) [Pubmed]
  3. Novel genetic components controlling invertase production in Saccharomyces cerevisiae. del Castillo Agudo, L., Zimmermann, F.K. J. Gen. Microbiol. (1987) [Pubmed]
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